Genzyme Corporation

Merck + Co., Inc.

University of Washington

Anormed, Inc.

David C Dale

Gary James Bridger

Michael J Abrams

Hal E Broxmeyer

Geoffrey W Henson

Ronald Trevor MacFarland

Gary B Calandra

Paul E Finke

Richard A Mumford

Andranik Andrew Aprikyan

Frank J Hsu

Ronald Trevor Macfarland

The invention is directed to a method of treating severe neutropenia, and in particular, cyclic neutropenia (CN) or severe congenital neutropenia (SCN), in a patient in need of such treatment comprising: administering a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof. 

Method of treating inherited severe neutropenia

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z'&#x2003;&#x2003;(1) 

Methods to mobilize progenitor/stem cells

Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and/or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.

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Seattle, WA, United States of America

David C Dale