Cranfield University

David C Cullen

Olena Volodimirivna Piletska

Uwe Schedler

Sergiy Anatoliyovich Piletsky

Anthony P F Turner

David Weston

Reaction of a dialdehyde, particularly phthaldialdehyde (I), with R&mdash;Z where Z is a nucleophilic group (preferably SH) and R is polymerisable (e.g. allyl) gives a reactive thioacetal (V) which can react with an amine ligand L&mdash;NH to produce an isoindole (IV) which may be fluorescent. At some stage, generally before interaction with L&mdash;NH , the R groups are polymerised, possibly leading to self-assembly of the polymer on a metal or SH-bearing surface. Such a coated surface is useful as a transducer in assays or as a binding medium e.g. for chromatography.

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Cambridge, United Kingdom

David C Cullen