Athersys, Inc.

Givaudan S.a.

Givandan S.a.

David C Bom

Youssef L Bennani

Michael J Robarge

Lawrence Nathan Tumey

Bayard R Huck

Esther Van Ommeren

L Nathan Tumey

Xiaogen Yang

Stefan Michael Furrer

Ioana Maria Ungureanu

Kimberley Gray

David Max Dastrup

Philip A Christenson

Rajesh Venkata Potineni

Norbert Varga

Jason Jordan

Robert G Eilerman

Eric Flamme

A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) wherein one of X, X, or Xis selected from the group consisting of S, N and O and the remaining two are CH; and A is selected from in which R, R, R, RR, Rare independently selected from the group consisting of H, methyl, ethyl, propyl, OH, OMe, OEt, COOH, COOR, in which Ris selected from linear or branched C-Calkyl, and CONRR, in which Rand Rare independently selected from hydrogen and straight or branched C-Calkyl; or any two adjacent substituents R-Rtogether form a ring of 5 or 6 members; and n is 1 or 0.

Methods of modifying or imparting taste using organic compounds

A method of modifying the taste of a consumable, comprising adding to a consumable base at least one compound of the formula I in which 

Taste modifiers

The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. addiction, anxiety, depression, obesity, and others).

[object Object]

A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, Ris selected from H and OMe, Ris selected from OH, OMe and OEt, and Ris selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.

Cooling compounds

The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

Acrylic n-hydroxy imides and their use in pharmaceutical compositions and in the inhibition of flap endonuclease are disclosed.

Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof

A method of making a compound of formula II comprising the reaction of a compound of formula RCONHwith a compound of formula III R being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base. The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.

Amide addition reaction

Substituted azepine derivatives as serotonin receptor modulators

Growing community of inventors

Cincinnati, OH, United States of America

David C Bom