University of Tennessee Research Foundation

The United States of America As Represented by the Department of Health

David C Baker

Shijia Yan

William G Rice

Louis E Henderson

Stephen C Johnson

Bin Jiang

Robert R Schultz

Prashant P Deshtande

Anand Mayasundari

Frank Tagliaferri

Jianmin Mao

Samuel F Victory

Jiammin Mao

The invention relates to a new class of compounds herein identified generally as &ldquo;sultams&rdquo;, which may be represented by the following formula V, in FIG. 1, in which numbering of the atoms is started with the sulfur atom of the isothiazole. Two of the rings (rings A and C) are aromatic, and the third is a heterocyclic ring (ring B), a cyclic sulfonamide. Of particular importance are the enantiomerically pure sultams since they are especially potent HIV-1 inhibitors.

Methods of synthesizing sultams and anti-viral compositions

Biologically active sultams are disclosed which have potent anti-HIV activity. Solution methods of syntheses, which use a new catalyst for the asymmetric reduction of a C&boxH;N intermediate, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.

Sultams: catalyst systems for asymmetric reduction of a C&equals;N intermediate biological compositions and methods for making the sultams

Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.

Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions

Anti-viral pharmaceutical compositions containing saturated

The invention relates to pyran-chromenone compounds, their synthesis and anti-HIV activity. Methods of synthesis are disclosed; the compounds have activity against reverse transcriptase. Biological compositions containing the compounds and method of treating patients are also disclosed.

Pyran-chromenone compounds, their synthesis and anti-HIV activity

A method of synthesis of the four optically active stereoisomers of calanolide A and B which produces the compounds in high yields and in a high degree of purity.

Synthesis of optically active calanolides A and B and enantiomers and

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Knoxville, TN, United States of America

David C Baker