Other

David Byers

Donald F Weaver

Fan Wu

Christopher McMaster

Chris Barden

Annette Henneberry

Fuqiang Ban

Chris Donald Barden

Fugiang Ban

The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

Synthesis of novel antimicrobials

Growing community of inventors

Halifax, Canada

David Byers