University of Montana

Glaxosmithkline Biologicals Sa

Children's Medical Center Corporation

David Burkhart

Jay Evans

Helene G Bazin-Lee

Kendal T Ryter

Alyson Jessica Smith

Michael Cochran

David A Johnson

George Ettenger

Daniel Larocque

Christopher W Cluff

Ofer Levy

David J Dowling

Jay T Evans

Craig L Johnson

Helene Bazin-Lee

Walid Abdelwahab Marzouky Abdelwahab

Alyson Smith

Julien St Jean

Nupur Dutta

Julien St-Jean

David Johnson

Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmnune disorders.

Vaccine adjuvants based on TLR receptor ligands

Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Diaryl trehalose compounds and uses thereof

Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.

Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.

Immunogenic trehalose compounds and uses thereof

The methods and compositions described herein relate to methods of immunization or stimulating an immune response, e.g., using agonists of TLR7 and/or TLR8 as antigens. The methods and compositions described herein have particular relevance to use in infants.

Methods and compositions relating to adjuvants

This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

Imidazoquinoline derivatives and their use in therapy

The present invention relates to immunogenic compositions and methods for producing them, and in particular, immunogenic compositions comprising a protein antigen cross linked to an oxoadenine adjuvant.

Compositions and uses

There is provided a composition comprising an aminoalkyl glucosaminide phosphate compound or a pharmaceutically salt thereof and a buffer for use as an immunomodulator.

Growing community of inventors

Hamilton, MT, United States of America

David Burkhart