Merrimack Pharmaceuticals, Inc.

Dyax Corporation

Other

Acceleron Pharma Inc.

David Buckler

Michael Feldhaus

Ulrik Bjerl Nielsen

Birgit Schoeberl

Arumugam Muruganandam

Ravindra Kumar

Asya Grinberg

Rachel B Kent

Monique V Davies

Laetitia Devy

Edward Hirsch Cohen

Janja Cosic

Diana Martik

Arumugam Muruganadam

Ulrick Nielsen

The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.

Polynucleotides encoding an actriib antibody

The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.

Antibodies against the ectodomain of ERBB3 and uses thereof

The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. For example, the antibodies described herein are capable of binding to ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor.

Antibodies against ERBB3 and uses thereof

Method of detection of neutralizing anti-actriib antibodies

Antibodies against the ectodomain of ErbB3 and uses thereof

Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described.

Metalloproteinase 9 binding proteins

The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. In a particular embodiment, the antibodies are capable of binding to ErbB3 and inhibiting ligand mediated phosphorylation of the receptor.

Antibodies against ErbB3 and uses thereof

Growing community of inventors

Chester, NJ, United States of America

David Buckler