Ares Trading S.a.

David Bruhlmann

Martin Jordan

Herve Broly

Matthieu Stettler

Anais Muhr

Hervé Broly

Gabrielle Leclercq

Jonathan Souquet

Thomas Vuillemin

Anaïs Muhr

The present invention relates to methods and compositions for modulating mannosylation profile of recombinant proteins expressed by mammalian host cells during the cell culture process, using a polyether ionophore.

Methods for modulating protein mannosylation profiles using maduramycin, narasin, or salinomycin

The present invention relates to methods and compositions for modulating glycosylation profile, such as the galactosylation profile, of recombinant proteins expressed by mammalian host cells during the cell culture process by supplementing cell culture media with a peracetyl galactose.

Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose

The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.

Methods for modulating production profiles of recombinant proteins

The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4'diisothiocyanostilbene-2,2&#x2032;-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.

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Lausanne, Switzerland

David Bruhlmann