Eli Lilly and Company

Amunix Operating Inc.

David Bruce Baldwin

Andrew Ihor Korytko

John Michael Beals

Gregory Alan Lazar

Jonathan Wesley Day

Craig Duane Dickinson

Volker Schellenberger

Bryant McLaughlin

The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Fusion proteins

An article of clothing provides workers or users with a modifiable or transformable bottom garment which may be arranged in a functional, work configuration or a more aesthetic, non-work configuration by selectively folding a cover assembly downward or upward relative to the bottom garment. When folded downward, the cover assembly may reveal functional elements such as tool-supporting loops, pockets, etc., and/or may provide an inner surface for the wearer to clean their hands. When folded upward, a pocket is instead formed between the cover assembly and the bottom garment, for the wearer to warm their hands. One or more inserts may be connected to the downward-folded cover assembly to provide additional utilities or functions.

Article of clothing with multi-purpose cover assembly

Fusion proteins and methods of use

The present invention relates to the field of medicine and the treatment of diabetes or hyperglycemia within that field. More particularly, the invention relates to a compound that lowers blood glucose, pharmaceutical compositions containing such a compound, and therapeutic uses of such a compound. The compound claimed herein comprises an A chain and a B chain, wherein the amino acid sequence of the A chain is SEQ ID NO: 1 and the amino acid sequence of the B chain is SEQ ID NO: 2.

Blood glucose lowering compound

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Carmel, IN, United States of America

David Bruce Baldwin