Rnaimmune, Inc.

David Brown

Yong-Sik Bong

Dong Shen

Patrick Y Lu

Shenggao Tang

Ziyang He

Chun Lu

Renxiang Chen

Jiaxi He

Neeti Ananthaswamy

Naihsuan C Guy

Ju Hyeong Jeon

Zhifeng Long

Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from an Omicron variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Composition and methods for MRNA vaccines against novel omicron coronavirus infections

Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

Compositions and methods of mRNA vaccines against novel coronavirus infection

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Gaithersburg, MD, United States of America

David Brown