Other

David Botstein

Ronald Levy

Robert Tibshirani

Izidore Lossos

Ash A Alizadeh

Mark A Wechser

Sanford Jay Silverman

Robert Scott McIsaac

Marcus Noyes

A system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that is responsive to hormone inducer. Upon addition of the hormone, cytoplasmic transcriptional activator localizes to the nucleus and subsequently binds to promoters containing sequences that bind to its DNA-binding domain. Genetic modifications allow for rapid and specific degradation of a targeted protein upon addition of hormone by means of a regulated degron method that utilizes a protease variant. This system is useful for discovering new compounds by high throughput screening when introducing compound libraries to these protein-depleted cells.

Systems for induction of gene expression and protein depletion in yeast

Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression values obtained from DLBCL patients can stratify patients in the classification groups. The methods and kits can be used to predict overall patient survival.

Classification of patients having diffuse large b-cell lymphoma based upon gene expression

Classification of patients having diffuse large B-cell lymphoma based upon gene expression

Growing community of inventors

Princeton, NJ, United States of America

David Botstein