The General Hospital Corporation

Children's Medical Center Corporation

The Mclean Hospital Corporation

Other

Bayer Pharmaceuticals Corporation

David Borsook

Lino Becerra

Jan William Wasley

David Alan Boas

Edward N George

Hans C Breiter

Jeffrey W Clark

Igor Elman

Eric A Moulton

Marnie Shaw

Ke Peng

An ongoing pain detection system and method are provided. The method includes obtaining imaging data from patient using functional near-infrared spectroscopy from at least one cortical region of the brain of a non-responsive patient and observing power spectral density variations in the signal. The measured imaging data is compared with patient pain based on control data to recognize ongoing pain in the non-responsive patient.

Ongoing pain detection system and method for utilizing near-infrared spectroscopy

The various examples of the present disclosure are directed towards systems and methods for diagnosing brain health. An exemplary system includes a microscope, a processor, and a memory. The microscope outputs image data of a cornea of a patient. The memory has a plurality of stored code sections, which, when executed by the processor, include instructions for analyzing cornea image data to determine brain health. The instructions begin with receiving cornea image data from the microscope. The instructions then provide for determining at least one marker from the received cornea image data. The instructions then provide for outputting a brain health diagnosis based on the at least one marker.

Systems and methods for analyzing concussion biomarkers

Disclosed is a pain detection system and method. Preferred methods include capturing imaging data from patient using functional near-infrared spectroscopy. In methods of the invention, pain may be assessed from a non-responsive patient. Preferred methods may further include measuring hemodynamic parameters using the optical imaging data and averaging the measured hemodynamic parameters to reduce background noise. Additionally, a pattern in the averaged hemodynamic parameters is identified and the pattern is compared to a predetermined associated with patient pain. The method further includes detecting, by the processor, a similarity between the pattern and the predetermined pattern and outputting a signal indicating patient pain.

Pain detection system and method utilizing near-infrared spectroscopy

A method for recognizing awareness in a subject includes performing optical imaging on at least one cortical region of the brain of the subject. Optical imaging data are obtained over time measuring one or more hemodynamic parameters in the at least one cortical region of the subject's brain. An observed variation pattern is determined in the measured hemodynamic parameters, and the observed variation pattern is compared to one or more known variation patterns characteristic of awareness. Substantial similarity between the observed and known variation patterns signals awareness in the subject.

Recognizing awareness in an anesthetized subject

In general, the invention provides methods and compositions for treating sequela of weight gain or pain insensitivity, e.g., in a subject suffering from a psychiatric disorder, such as schizophrenia. The combinations employed in the invention include a second generation antipsychotic agent and an opioid receptor antagonist.

Treatment of sequelae of psychiatric disorders

In general, the invention features methods for identifying therapeutic interventions for functional illnesses, e.g., neuropathic pain or depression, and methods for identifying markers for functional illnesses by employing an acute painful stimulus or other stimulus for a functional illness and measuring levels of CNS activity.

CNS assay for prediction of therapeutic efficacy for neuropathic pain and other functional illnesses

Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.

Methods of decreasing or preventing pain using spicamycin derivatives

Methods for decreasing or preventing pain using spicamycin derivatives

A method for measuring indices of brain activity includes non-invasively obtaining signals of central nervous system (CNS) activity, localizing signals to specific anatomical and functional CNS regions, correlating the signals from pain and reward brain regions, and interpreting the correlation results. The results of interpreting the correlation results can be used for objectively measuring, in individual humans or animals, their responses to motivationally salient stimuli including but not limited to stimuli which are internal or external, conscious or non-conscious, pharmacological or non-pharmacological therapies, and diseased based processes. This method for measuring brain activity in reward/aversive central nervous system regions, can further be used to determine the efficacy of compounds.

Method and apparatus for objectively measuring pain, pain treatment and other related techniques

Methods of providing pain relief which includes the steps of identifying an animal in need of pain relief and administering an amount of spicamycin or a derivative thereof sufficient to provide pain relief.

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Concord, MA, United States of America

David Borsook