Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Centre National De La Recherche Scientifique

Institut Pasteur

Université Paris—sud

Societe Nationale Elf Aquitaine

Université Grenoble Alpes

Université Paris-sud 11

Université Paris Sud Xi

David Bonnaffe

Françoise Baleux

Hugues Lortat-Jacob

Thierry Livache

Isabelle Texier-Nogues

Jean-Louis Seris

Yves-Marie Coic

Yanxia Hou-Broutin

Aude Bernardin

Arnaud Buhot

Andre Lubineau

Latino Loureiro-Morais

Michel Therisod

Yves-Marie COÏC

The present invention relates to a sensor for an electronic tongue or nose for analysing a sample or detecting a target. The sensor comprises a support, on one surface of which a plurality of sensitive areas are located, each sensitive area comprising at least one receptor and being capable of transmitting a measurable signal generated by the interaction of at least one constituent of the sample or one target with at least one receptor. The sensor is characterised in that it comprises at least three sensitive areas that differ from one another in terms of their respective receptor compositions, at least one of the sensitive areas comprising a mixture of at least two different receptors, while the two other sensitive areas each comprise at least one of the two receptors.

Electronic nose or tongue sensors

This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.

Conjugated molecules comprising a peptide derived from the CD4 receptor coupled to an anionic polypeptide for the treatment of AIDS

This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.

Conjugated molecules comprising a peptide derived from the CD4 receptor  coupled to a polyanion for the treatment of AIDS

Conjugated molecules comprising a peptide derived from the CD4 receptor coupled to a polyanionic polypeptide for the treatment of AIDS

The present invention is targeted at a novel coupling method of 1,3-dipolar cycloaddition type which is of particular use for the functionalization of biological molecules, such as, for example, proteins, enzymes or nucleic acids, insofar as it can be carried out in an aqueous medium and at ambient temperature.

Process for the functionalization of biological molecules

Method for the chemical modification of proteins using a reagent of general formula ##STR1## obtained from the diene ##STR2## and maleic anhydride by Diels-Alder addition.

Method for the chemical modification of proteins

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Paris, France

David Bonnaffe