Boston Scientific Neuromodulation Corporation

Intelect Medical, Inc.

The Medical College of Wisconsin, Inc.

David Blum

Keith R Carlton

Scott Kokones

Troy Sparks

Michael A Moffitt

Jordan Barnhorst

Hemant Bokil

Arna Diana Ionescu

David Lubensky

Brian Hoffer

Alan Greszler

Gregory T Schulte

Engin Erdogan

Karl Steinke

Sherry Lin

Pramodsingh Hirasingh Thakur

David J Ternes

Stephen B Ruble

Bryan Allen Clark

G Karl Steinke

Craig Michael Stolen

Michael X Govea

Peter J Yoo

Christopher R Butson

William Conrad Stoffregen

A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.

Systems and methods for closed-loop determination of stimulation parameter settings for an electrical simulation system

Methods and systems for selecting electrical stimulation parameters for an electrical stimulation device implanted in a patient can use an iterative process for identifying electrodes for stimulation, as well as suitable stimulation parameters. The process begins with an initial set of electrode combinations to identify regions of the nerve or other tissue for stimulation. This leads to selection of other electrode combinations to test, followed by the selection of multiple electrode groups (which can include three or more electrodes) for stimulation.

Methods and systems for selecting stimulation parameters for electrical stimulation devices

A method for generating a clinical effects map for electrical stimulation using an electrical stimulation lead includes receiving at least one clinical response for stimulation using each of multiple first sets of stimulation parameters where each clinical response is associated with at least one therapeutic effect or side effect. The method also includes determining, using the clinical responses and the first sets of stimulation parameters, a spatial relationship between the electrical stimulation lead and at least one effect region, where each effect region is associated with at least one of the therapeutic effects or side effects; estimating, based on the spatial relationship, at least one clinical response for each of multiple second sets of stimulation parameters; and generating and presenting a clinical effects map illustrating at least the estimated clinical response for one or more of the second sets of stimulation parameters.

Systems and methods for estimating clinical effects of electrical stimulation

A system and method may include determining a target stimulation volume based on modifying a patient population image for which an efficacious volume had been determined. A system and method for suggesting stimulation devices may include determining which stimulation device is capable of producing an output volume of activation that most closely matches the target volume. A system and method for facilitating selection of stimulation parameters may include graphically identifying a maximum volume in which tissue is stimulatable by an implanted stimulation device. A system and method may pre-compute volumes of activation that result from a predetermined modification of programming settings. A system and method may transmit stimulation programming settings from a stimulation programming module to a stimulation generating device.

System and method for determining target stimulation volumes

A tool for assisting in the planning or performing of electrical neuromodulation of a patient's spinal cord. The tool may have various functions and capabilities, including calculating a volume of activation, registering an electrode(s) shown in a radiologic image, constructing functional images of the patient's spinal anatomy, targeting of neuromodulation, finding a functional midline between multiple electrodes, determining the three-dimensional position of multiple electrodes, and/or accommodating for electrode migration. In certain embodiments, the tool can be embodied as computer software or a computer system.

Programming interface for spinal cord neuromodulation

A system and method for generating an estimated volume of activation (VOA) corresponding to settings applied to a stimulation leadwire includes a processor performing the following: determining, for each of a plurality of neural elements, one or more respective parameters characterizing an electrical distribution along the neural element, looking up the one or more parameters for each of the neural elements in a look-up table (LUT), obtaining threshold values for each of the neural elements recorded in the LUT in association with the looked-up parameters, comparing, for each of the neural elements, a value of the leadwire settings to each of the respective threshold value, estimating based on the comparisons which of the neural elements would be activated by the settings, and generating a structure corresponding to a region including the neural elements estimated to be activated.

VOA generation system and method using a fiber specific analysis

A system and method for associating anatomically significant regions with regions of one or more images may include automatically modifying images of different modalities according to different correction algorithms, providing a user interface for identifying a plane within three-dimensional data, scaling atlas structures to fit an anatomical image according to identified landmarks, registering an atlas to such an image via a combination of registration algorithms, and/or registering an atlas to such an image using a feature extraction algorithm.

System and method for atlas registration

A system and method for displaying a volume of activation (VOA) may include a processor that displays via a display device a model of a portion of a patient anatomy that includes anatomical structures, displays via the display device and overlying the display of the model a VOA associated by the processor with a set of anatomical stimulation parameter settings, the display of the VOA, and graphically identifies interactions between the displayed VOA and a first subset of the anatomical structures associated with one or more stimulation benefits and a second subset of the anatomical structures associated with one or more stimulation side effects, where the graphical identifications differ depending on whether the interaction is with the first subset or the second subset.

Clinician programmer system and method for generating interface models and displays of volumes of activation

A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Clinician programmer system and method for steering volumes of activation

Growing community of inventors

Boston, MA, United States of America

David Blum