Astrazeneca Ab

David Blomberg

Ingemar Starke

Mikael Ulf Johan Dahlstrom

Suzanne Alenfalk

Malin Anita Lemurell

Peter Nordberg

Andreas Christer Wallberg

Tore Skjaret

Stig Jonas Bostrom

Mickael Dahlström

The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described 

Benzothiepine ileal bile acid transport inhibitors

The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described 

Benzothiazepine derivatives

The present invention relates to compounds of formula (I), wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described 

The present invention relates to compounds of formula (I) wherein R, R, R, R, R, M, R, v, R, R, Rand Rare as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described. 

Benzothiazepine and benzothiazepine derivatives with ileal bile acid transport (IBAT) inhibotory activity for the treatment hyperlipidaemia

The present invention relates to compounds of formula (I): wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidemia. Processes for their manufacture and pharmaceutical compositions containing them are also described 

Benzothiazepine derivatives for the treatment of hyperlipidemia

The present invention relates to compounds of formula (I) wherein Rand Rare independently selected from Calkyl; one of Rand Ris a group of formula (IA): R, R, R, R, R, Rand Rand the other of Rand Rare as defined within, pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and there use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

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Molndal, Sweden

David Blomberg