Cyclacel Limited

David Blake

Daniella I Zheleva

Peter Martin Fischer

Simon Richard Green

Shudong Wang

Judy H Chiao

Susan Davis

Gavin Wood

Christopher Meades

Geoffrey I Shapiro

Janice McLachlan

Kenneth Duncan

Darren Gibson

Alex Perry

Kenneth W Duncan

Janice C Mclachlan

A first aspect of the invention relates to a method of treating a proliferative disorder in a subject, said method comprising administering to the subject a therapeutically effective amount of (i) sapacitabine, or a metabolite thereof; and (ii) seliciclib; in accordance with a dosing regimen comprising at least one first treatment cycle and at least one second treatment cycle, wherein said first treatment cycle comprises: (a) administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 3 to 5 consecutive days for 2 weeks, starting on day d, where d is the first day of treatment with sapacitabine, or the metabolite thereof, in said first treatment cycle; and (b) optionally administering a therapeutically effective amount of seliciclib for 3 to 5 consecutive days for 2 weeks, starting on day (d&#x2212;1) relative to the administration of sapacitabine or the metabolite thereof, in said first treatment cycle; followed by a rest period of at least 2 weeks, or until treatment-related toxicities are resolved, whichever is longer; and wherein said second treatment cycle comprises: (a) administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 3 to 5 consecutive days for 2 weeks, starting on day d, where d is the first day of treatment with sapacitabine, or the metabolite thereof, in said second treatment cycle; and (b) administering a therapeutically effective amount of seliciclib for 3 to 5 consecutive days for 2 weeks, starting on day (d&#x2212;1) relative to the administration of sapacitabine or the metabolite thereof, in said second treatment cycle; followed by a rest period of at least 2 weeks, or until treatment-related toxicities are resolved, whichever is longer. Further aspects of the invention relate to a kit of parts, and corresponding uses.

Dosage regimen for sapacitabine and seliciclib

The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein Rand Rare each independently H, C(OR) or a hydrocarbyl group optionally substituted by one or more Rgroups; Further aspects of the invention relate to pharmaceutical compositions comprising such compounds, and their use in the preparation of a medicament for treating one or more of the following: a proliferative disorder, a viral disorder, a CNS disorder, a stroke, alopecia and diabetes.

Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy

Growing community of inventors

Angus, United Kingdom

David Blake