The Procter Gamble Company

The Cleveland Clinic Foundation

David Blair Cody

Stanley Leon Hazen

John August Wos

Jose Carlos Garcia-Garcia

Michael Reilly

George Franklin Gerberick

David Thomas Stanton

Jodie Michele Reed

Mark Robert Sivik

Jun Xu

Charles Winston Saunders

Phillip Richard Green

Thomas Alfred Inglin

Angela Jane Deutsch

Xiaodong Gu

Jodie Michelle Reed

Zubin Sarosh Khambatta

Xiandong Gu

A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I): 

Methods for inhibiting conversion of choline to trimethylamine (TMA)

The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.

Methods for inhibiting conversion of carnitine to trimethylamine (TMA)

The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.

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West Harrison, IN, United States of America

David Blair Cody