Adir Et Compagnie

David Billington

Alain Pierre

Ghanem Atassi

Nicolas Guilbaud

Michael Burbridge

Isabelle Picard

Jacques Duhault

Gilbert Dorey

Joseph Espinal

Pascale Leon

Compounds of formula (I): ##STR1## wherein: R is selected from the radicals: ##STR2## Y is selected from ##STR3## R.sub.1 represents the radical ##STR4## and A, B, C, D, R.sub.2, R.sub.3 and R.sub.4 are as defined in the description, and also the possible geometric isomers and/or diastereoisomers and/or enantiomers thereof in pure form or in the form of a mixture. The compounds of the present invention have a therapeutic use as a result of their angiogenesis-inhibiting activity.

Cyclohexane compounds

A compound selected from those of formula (I): ##STR1## in which: A either represents --OR.sub.6, and B represents --CH.sub.2 --X,

Tetrahydropyran compounds

A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R'.sub.1 and R.sub.2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R.sub.2 groups being in the cis position in relation to the rings,

Naphthalene compounds

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Birmingham, United Kingdom

David Billington