Johnson & Johnson Gmbh

Ortho-clinical Diagnostics, Inc

Cytiva Sweden Ab

David Bergman

Zhong Ding

Mats Lundkvist

Ib Mendel-Hartvig

Hanno Ehring

Simon Uhrberg

Annika Lindström

Andreas MARCSTRÖM

An assay device includes: a liquid sample receiving zone; a capture zone in fluid communication with the sample receiving zone having capture elements bound thereto, the capture zone having a substrate and projections which extend substantially vertically from the substrate, the projections having a rhombus-shaped cross-section and the projections arranged on the substrate with the corners of the projections facing upstream in a direction toward the sample receiving zone. The projections have a height, cross-section and a distance between one another that defines a capillary space between the projections capable of generating capillary flow parallel to the substrate surface; and a sink in fluid communication with the capture zone having a capacity to receive liquid sample flowing from the capture zone. The sample receiving zone, the capture zone and the sink define a fluid flow path. Preferably, the rhombus-shaped cross-section is a square or a diamond.

Assay device having rhombus-shaped projections

A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting the receiving and reaction zone, respectively, forming a flow path on a substrate, wherein said substrate is a non-porous substrate, and at least part of said flow path consists of areas of projections substantially vertical to said surface, and having a height (H), diameter (D) and reciprocal spacing (t, t) such, that lateral capillary flow of said liquid sample in said zone is achieved, and where means for separation are provided adjacent to the zone for receiving the sample. Said means for separation are chosen among filter means, optionally enhanced by affinity binding and/or aggregation; magnetic means, also optionally enhanced by affinity binding and/or aggregation; and acoustic means.

Assay device and method

There is disclosed an analysis device for the analysis of a liquid sample, said device comprising a substrate, said substrate at least partly having projections substantially vertical to the surface of said substrate, and having a height (H), diameter (D) and center-to-center distance (x, y) such, that lateral capillary flow of said liquid sample is achieved, wherein that said substrate comprises at least one substrate zone comprising projections substantially vertical to the surface of said substrate, and having a height (H), diameter (D) and center-to-center distance (x, y), such, that lateral capillary flow of said liquid sample is achieved and wherein at least one substance is applied at least partly between the projections in said at least one substrate zone. Moreover there is provided a method for the analysis of a sample. The device and method provide for instance improved control of the dissolution of a substance.

Assay method utilizing capillary transport on non-porous substrates

Growing community of inventors

Uppsala, Sweden

David Bergman