Trisalus Life Sciences, Inc.

Surefire Medical, Inc.

David Benjamin Jaroch

James E Chomas

Aravind Arepally

Bryan Pinchuk

Patrick Charles McCain

Erik Dean Olson

Jennifer D Lucky

Mike Bojanowski

Patrick Charles Mccain

An atraumatic vessel occlusive system includes a flexible tubular member with an infusion lumen, a vessel occluder mounted at the distal end of the tubular member, and a pressure sensor located within a chamber defined by the occluder. The occluder has a braided construct provided with a fluid impermeable membrane over its proximal portion and a fluid permeable covering over its distal portion. The pressure sensor is adapted to sense pressure within the vessel through the fluid permeable membrane without being subject to the effects of turbulent flow at the exit of the infusion lumen. The accurately sensed pressure can be used to determine a dwell time for the occluder.

Atraumatic occlusive system with compartment for measurement of vascular pressure change

A treatment system includes a guide sheath, and a catheter provided with a pressure-controlled element. The pressure-control element preferably includes an expanded configuration adapted to extend across a small feeder vessel branching from the splenic vein. The pressure-control element is positioned with the feeder vessel, and a therapeutic agent is delivered under pressure directly into the feeder vessel, where it is forced to penetrate deep into tissue. Pressure responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ. Methods for treating tissues and organs via vascular pathways are provided.

System and method for selective pressure-controlled therapeutic delivery

A method for delivering a therapeutic agent to a tumor through a target vessel includes delivering the therapeutic agent through a lumen of a catheter which has been coated or otherwise structured to reduce the wall shear stress during delivery of the immunotherapy and by generating turbulent flow during the delivery of the therapeutic agent.

Method of delivering a therapeutic agent to a solid tumor for treatment

Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.

Dual pathway therapeutic agent delivery

A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at a distal end of the catheter. The pressure sensor system is provided to sense pressure at a distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control a rate of infusion of a therapeutic agent through the catheter lumen based on the pressure sensed by the pressure sensor system. A method includes deploying the vascular occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure in the vessel.

Systems and methods for pressure-facilitated therapeutic agent delivery

A treatment system includes a dual lumen catheter system. The first lumen is open to systemic circulation. The second lumen is open to a target delivery location. In an embodiment, a pressure-control element is provided that includes an expanded configuration adapted to constrain delivery through the second lumen to the target delivery location. Methods for treating tissues and organs via vascular pathways are provided.

Implantable dual pathway therapeutic agent delivery port

A method for delivering an immunotherapy agent to a tumor includes advancing the delivery device into a vessel of a patient, and infusing the agent under pressure into the vessel to penetrate the tumor. The delivery device prevents reflux of the agent toward non-treatment sites.

Method for infusing an immunotherapy agent to a solid tumor for treatment

A guiding catheter has a proximal portion constructed of a tubular braid and a shape-retentive distal portion including a superelastic hypotube cut to define particular mating, support, shape-retentive and flexibility characteristics. A tubular liner extends through both of the tubular braid and the hypotube. The hypotube is joined to the braid using a mechanical interlock that has high torque transfer from the braid to the hypotube. A short portion of high stiffness polymer tube is provided at a joint between the braid and the hypotube. A polymeric outer jacket is provided over the proximal and distal portions, including the polymer tube. The jacket is heat set over the hypotube to remove residual stress.

Guiding catheter having shape-retentive distal end

A treatment system includes a guide sheath, and a catheter provided with a pressure-controlled element. The pressure-control element preferably includes an expanded configuration adapted to extend across a small feeder vessel branching from the splenic vein. The pressure-control element is positioned with the feeder vessel, and a therapeutic agent is delivered under pressure directly into the feeder vessel, where it is forced to penetrate deep into tissue. Pressure responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ.

An endovascular microvalve device for use in a vessel during a therapy procedure includes a catheter and a filter valve coupled to the catheters. The filter valve is dynamically reconfigurable to automatically block and permit fluid flow through a vessel based on a local fluid pressure conditions about the filter valve. In embodiments, the filter valve has a proximal end fixed to the catheter, and a distal end which may be movable over the catheter. The lumen of the inner catheter delivers a therapeutic agent beyond the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.

Dynamic reconfigurable microvalve protection device

An endovascular microvalve device for use in a vessel during a therapy procedure includes an outer catheter, an inner catheter displaceable within the outer catheter, and a filter valve coupled to the distal ends of the inner and outer catheters. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the inner catheter delivers a therapeutic agent beyond the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.

Growing community of inventors

Arvada, CO, United States of America

David Benjamin Jaroch