Glaxosmithkline Intellectual Property (No.2) Limited

Anacor Pharmaceuticals, Inc.

Glaxo Group Limited

David Barros-Aguirre

Jacob J Plattner

Vincent S Hernandez

Xianfeng Li

Ilaria Giordano

Carlos Alemparte-Gallardo

Michael Richard Kevin Alley

Jose Maria Fiandor Roman

Michael Richard Kevin (Dickon) Alley

Monica Cacho-Izquierdo

Neil David Pearson

Alan Joseph Hennessy

Jose Luis Lavandera Diaz

Modesto Jesús Remuiñan-Blanco

Christopher Barfoot

Modesto Jesus Remuinan-Blanco

Julia Castro-Pichel

Lluis Ballell-Pages

Jose Maria Fiandor-Roman

Mrk (dickon) Alley

Vincent Hernandez

MRK Alley

Substituted benzoxaboroles whose structure comprises Formula (III), wherein Ris selected from &#x2014;CH, &#x2014;CIICII, &#x2014;CII&#x2550;CII, &#x2014;CIICIICII, &#x2014;CH(CH), &#x2014;CHCH&#x2550;CH, and cyclopropyl, Rand Rare each independently selected from H, &#x2014;CH, &#x2014;CHCH, &#x2014;CHCHCH, and &#x2014;CH(CH); compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.

4-substituted benzoxaborole compounds and uses thereof

Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, Rand Rare each independently selected from H, &#x2014;CH, &#x2014;CHCH, &#x2014;CHCHCH, or &#x2014;CH(CH); compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.

Tricyclic benzoxaborole compounds and uses thereof

Substituted benzoxaboroles whose structure comprises Formula (III), wherein Ris selected from &#x2014;CH, &#x2014;CHCH, &#x2014;CH&#x2550;CH, &#x2014;CHCHCH, &#x2014;CH(CH), &#x2014;CHCH&#x2550;CH, and cyclopropyl, Rand Rare each independently selected from H, &#x2014;CH, &#x2014;CHCH, &#x2014;CHCHCH, and &#x2014;CH(CH); compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided. 

Compounds of Formula (I), wherein substituents R, Rand Rare as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl substituted by a hydroxyalkyl substituent and an optional other substituent; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

Naphthyridin-2 (1 H)-one compounds useful as antibacterials

Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them are described.

Compounds

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Madrid, Spain

David Barros-Aguirre