Ampio Pharmaceuticals, Inc.

Aytu Bioscience, Inc.

Dmi Biosciences, Inc.

Dmi Acquisition Corp.

Ischemia Technologies, Inc.

Other

Luoxis Diagnostics, Inc.

Diagnostic Markers, Inc.

Institute for Molecular Medicine, Inc.

Dmi Life Sciences, Inc.

Appenditech, Inc.

Optical Biopsy Technologies, Inc.

Ischemia Techologies, Inc.

Optical Biopsy

Insignia Pharmaceuticals, LLC

David Bar-Or

Raphael Bar-Or

Leonard T Rael

Nagaraja K R Rao

James V Winkler

Greg Thomas

Richard Shimonkevitz

C Gerald Curtis

Edward Lau

Clive Solomons

Francis A Roth

Kimberly B Bjugstad

Holli Cherevka

Ashok Agarwal

Rakesh Sharma

James S Kimmel

Sajal Gupta

Hollie Wayment

Gary Fagan

Wannell M Crook

Richard Shimonkovitz

Melissa Hausburg

Stewart L Greisman

Jon G Kastendieck

Raphael Bar-or

Gregory Thomas

Elizabeth Frederick

Jason Williams

Nagaraja K Rao

The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.

Pharmaceutical compositions for treating osteoarthritis

The invention provides a method, composition and kit for treating T-cell mediated diseases, degenerative joint diseases or diseases mediated by platelet activating factor (PAF) comprising administering to an animal in need thereof, an effective amount a pharmaceutical composition containing N-acetyl-kynurenine (NAK) or pharmaceutically acceptable salts thereof as the active ingredient.

Treatment of disease with n-acetyl kynurenine

The present invention provides a method of modulating various aspects of the immune system. In particular, the present invention teaches the use of diketopiperazines (DKPs) to modulate various aspects of the immune system such as, for example, inflammation, T-cells and various cytokines.

Use of low molecular weight fractions of human serum albumin in treating diseases

The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.

Treatment of T-cell mediated diseases

The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.

Methods for treating diseases associated with respiratory viruses

The invention provides a method of treating a joint condition. The method comprises administering a multi-dose regimen of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a method of treating osteoarthritis with multiple doses of a low-molecular weight fraction of human serum albumin.

Treatment of joint conditions

The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).

Implantable medical devices with increased immune tolerance, and methods for making and implanting

The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.

Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same

The invention provides a method of treating rhinitis. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP) formulated for nasal administration. The invention also provides a pharmaceutical product comprising a DA-DKP containing composition.

Treatment of rhinitis

The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.

Treatment of degenerative joint disease

Methods and systems for measuring and using the oxidation-reduction potential (ORP) of a biological sample are provided. The system generally includes a test strip and a readout device for determining the ORP. The measured ORP is then used to determine characteristics relating to the fertility of the sample or the subject from which the sample was derived. Some characteristics that can be determined include the quality of a sperm sample, an oocyte or a fertilized egg. The measured ORP value can also be used to determine the specific characteristics of a spermatozoa sample, such as the morphology of the spermatozoa, the motility of the spermatozoa, the number of cells in the sample and the concentration of the cells in the sample. Knowledge of such characteristics and fertility potential can be used to identify individuals that might benefit from specific fertility treatments.

Determination of fertility potential from the oxidation-reduction potential of a biological sample

Growing community of inventors

Englewood, CO, United States of America

David Bar-Or