Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Gpc Biotech Ag

David Bancroft

Hans Lehrach

Erich Wanker

Elmar Maier

Sebastian Meier-Ewert

Niels Wedemeyer

Markus Kietzmann

The present invention relates to an improved method for the identification and optionally the characterisation of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by conventional two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention provides for high-throughput interaction screens for the reliable identification of interacting molecules, which in turn can lead to the identification of substances inhibiting said interactions. Such inhibitors can find their use in the formulation of a pharmaceutical composition. The present invention further relates to kits useful for carrying out the method of the invention.

Method for the identification and characterization of interacting molecules by automated interaction mating

The present invention relates to an improved method for the identification and optionally the characterization of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention further relates to a kit useful for carrying out the method of the invention. The present invention provides for parallel, high-throughput or automated interaction screens for the reliable identification of interacting molecules.

Identification and characterization of interacting molecules

A plant is provided for rapid pick and place operations, enabling automated systems that return to at least one approximately fixed position to run faster than the rate of conventional systems. The plant utilises a novel combination of robotic design, linear motor technology, and control software. A system and method if provided for the rapid production of high-density arrays of biologically active substances.

Pick and place robot system

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Gilching, Germany

David Bancroft