University of Colorado

Other

Jingle Technologies LLC

University of Virginia Patent Foundation

Indiana University

University Technology Corporation

The University of Salford

Cancer Research Campaign Tech (london)

David B Ross

Charles Taylor

Michael Fitzpatrick Wempe

Dan Theodorescu

Phillip Reigan

David R Siegel

Chao Yan

Samy O Meroueh

Martin A Schwartz

Christopher J Moody

Philip Reigan

Wenchang Guo

William D Lloyd

John Butler

Brenda Faye Ross

Christopher S P McErlean

Daniel L Gustafson

Marie A Colucci

Howard D Beall

Donna Dehn

Robert H Hargreaves

David Siegal

Russell Richard Anthony Kitson

The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Anti-cancer compounds targeting Ral GTPases and methods of using the same

A microwave heatable composite material that comprises: a heat resistant moldable base material; a microwave heatable material dispersed in the heat resistant moldable base material; and a phase change material dispersed in the heat resistant moldable base material. The mixture of the microwave heatable material, heat resistant moldable base material, and phase change material provide a basic or core microwave heatable article layer to which one or more additional controlled heat releasing and/or heat transfer blocking layers can be combined to enhance and optimize heat therapy. In addition, the microwave heatable articles of the present invention can be used for cold therapy by lowering their temperatures in a freezer of similar cold environment.

Microwave heatable compositions and articles made therefrom

Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

Anti-cancer compounds targeting ral GTPases and methods of using the same

A method for evaluating pain experienced by a human is disclosed. The method includes applying a first noxious stimulus to a normative site on the human, wherein the first noxious stimulus is applied below a pain threshold of the human and logging a first information associated with the first noxious stimulus. The method further includes applying a second noxious stimulus to a source of the pain in the human, wherein the second noxious stimulus is applied until pain threshold is reached and logging a second information associated with the second noxious stimulus. The method further includes increasing the second noxious stimulus until pain tolerance is reached and logging a third information associated with the second noxious stimulus. The method further includes continuing to apply the second noxious stimulus until the human can no longer tolerate the second noxious stimulus and logging a fourth information associated with the second noxious stimulus.

Evaluation of pain in humans

The present invention generally relates to systems and methods for sharing information related to a location also referred to herein as a 'spot,' such as spot alerts and/or spot comments (e.g., shared information, advertisements, etc.) received, displayed, played, and/or actuated, for example, on recipient mobile electronic devices proximately located to such location (e.g., spot). Users of the system can create spot alerts in which designated recipients can receive messages, such as spot alerts and/or spot comments (e.g., shared information, advertisements, etc.) received, displayed, played, and/or actuated, for example, on respective recipient mobile electronic devices, when located within a proximity of a defined location (e.g., spot).

Systems and methods for transmitting information, alerts, and/or comments to participants based on location information

The invention provides indole-4,7-dione derivatives useful for the treatment of diseases in a mammal, pharmaceutical compositions containing the same and methods of using the same in the treatment of cancer and neoplastic diseases including human solid tumors and other mammalian tumors.

Indole derivatives and methods of using the same

The invention provides 19-substituted geldanamycin derivatives, and pharmaceutically acceptable salts thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer or neurodegenerative disorders.

HSP90 inhibitors with modified toxicity

Growing community of inventors

Southwest Ranches, FL, United States of America

David B Ross