Pall Corporation

Other

David B Pall

Thomas C Gsell

Brian T Muellers

Peter J Degen

Vlado I Matkovich

Thomas J Bormann

Colin F Harwood

Richard L Manteuffel

John D Miller

Irving B Joffee

Warren M Foss

Arthur Bradley

Timothy R Brennan

Stephen A Geibel

Tony Alex

Harvey Brandwein

Michael R Gildersleeve

James T Connors, Jr

Charles J Roach

Isaak Vasserman

John Mischenko, Iii

Frank Model

Abraham Krasnoff

Eleni C Yanakis

Fibrous web for processing a fluid

A method for bonding a porous medium to the surface of a solid substrate is disclosed. The method comprises contacting a dry porous medium with a dry surface of a substrate and impregnating the porous medium with a bonding composition. The impregnated porous medium is maintained in contact with the substrate surface until the substrate surface is at least slightly dissolved in the bonding composition without dissolving the porous medium. At least a portion of the bonding composition is flushed through the impregnated porous medium towards the substrate and subsequently away from the surface of the substrate. The bonding composition is then evaporated at a controlled rate from the substrate and the porous medium.

Method for bonding a porous medium to a substrate

Melt-blown fibrous webs having a uniform structure for use in processing biological fluids are disclosed.

Composite structure having a porous filter medium and a method for

The present invention provides a filtration method comprising passing a protein-containing solution through a filtration medium comprising a polyamide-polyether copolymer, such as a polyamide/polyalkylene-oxide-diamine, particularly a nylon 6/polyethylene-oxide-diamine copolymer.

Method of filtering a protein-containing fluid

A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.

System and method for processing biological fluid

Device and method for separating plasma from a biological fluid

The present invention provides a bag filter comprising a melt-blown fibrous nonwoven web formed into a bag configuration with a closed end, an open end, an inside surface, and an outside surface. The bag filter is constructed such that (a) the fibrous nonwoven web comprises fibers such that 90% of the fibers have a diameter ranging from a minimum fiber diameter to a maximum fiber diameter which is no more than about three times the minimum fiber diameter, (b) the fibrous nonwoven web as oriented in the bag filter has a tensile strength in the circumferential direction at least about 1.5 times the tensile strength in the longitudinal direction, and/or (c) there is no side seam and an injection-molded thermoplastic elastomer end closure. The present invention also provides a method of treating a fluid by passing the fluid through such a bag filter.

Bag filter

System for processing biological fluid

The present invention provides a melt-blown fibrous nonwoven web comprising fibers ranging in average fiber diameters to about 2 microns or less, with a narrow fiber diameter distribution, and a high degree of weight uniformity. The present invention also provides methods of preparing, processing and using such fibrous webs, as well as products incorporating such fibrous webs.

Melt-blown fibrous web

A method for preparing platelets comprises the steps of obtaining whole blood from human, preparing platelet rich plasma from the whole blood and then passing the platelet rich plasma through a filter comprising a porous medium having a CWST of at least about 70 dynes/cm, under conditions sufficient to remove in excess of about 99.99% of the leucocytes from the platelet rich plasma, with preparing platelet rich plasma and passing the platelet rich plasma through the filter occurring in an integrally-attached blood bag system within a few hours of obtaining whole blood from human.

Method for preparing platelets

A device for processing donated blood comprises a porous medium interposed between the collection bag and a satellite bag into which a component separated by centrifugation can be expressed, the filter element preferably having a CWST of about 70 to about 115 dynes/cm. The porous medium blocks red blood cells, but allows platelets to pass therethrough.

Method for processing blood for human transfusion

A high efficiency leucocyte-depletion filter for use with packed red cell concentrate derived from freshly drawn blood comprises a fibrous filter medium with a pore size of from about 0.5 to less than 3.6 .mu.m and a CWST of from 53 to about 80. The filter is preferably used in conjunction with a gel prefilter and, optionally, a microaggregate filter so as to minimize clogging. In a preferred embodiment, the voids volume is about 60% to about 85%.

Device for depletion of the leucocyte content of blood and blood

A method for bonding a porous medium to a substrate is provided which includes contacting a porous medium with a surface of a substrate, impregnating the porous medium with a bonding composition, maintaining the impregnated porous medium in contact with the substrate surface until the substrate surface is at least slightly dissolved in the bonding composition without dissolving the porous medium, and passing the bonding composition through the impregnated porous medium towards the substrate and subsequently away from the surface of the substrate to remove bonding composition containing dissolved substrate from a portion of the porous medium to minimize blockage of pores in the porous medium.

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Roslyn Estates, NY, United States of America

David B Pall