Verseon Corporation

Altera Corporation

Pts Corporation

Callida Genomics, Inc.

Nuvelo, Inc.

Verseon International Corporation

David B Kita

Adityo Prakash

Kevin Michael Short

Radoje Drmanac

Snezana Drmanac

Eniko Fodor

Son Minh Pham

Edward R Ratner

David Charles Williams

Oliver W Shih

Michial Allen Gunter

Chongjun Xu

Carroll Philip Gossett

Maria De Los Angeles Estiarte-Martinez

Cory Cooke

Tser-Yuan Brian Yang

Lewis T Williams

Giulia C Kennedy

Michael A Innis

Klaus Giese

Christoph Reinhard

Jaime A Escobedo

Filippo M Randazzo

David Pot

Pablo Dominguez Garcia

Ivan Labat

Somalee Datta

Altaf Kassam

George Lamson

Julie Sudduth-Klinger

Birgit Stache-Crain

Radomir Crkvenjakov

Mark Dickson

Dena Leshkowitz

Veronica Garcia

Lee William Jones

Dylan SeLegue

Hitoshi Watanabe

Sachin Ahuja

Gary R Holt

Schuyler Cullen

Rasmus Larsen

Nilantha Sudath Sirisoma

Timothy Philip Shiau

Thrombin-inhibiting acylated pyrazole-pyridone compounds of formula (II) are disclosed herein, as well as pharmaceutical compositions, including tablets, that contain acylated pyrazole-pyridone compounds. These compounds are useful for the treatment and prevention of thrombin-related related diseases and disorders. Processes for making tablets containing acylated pyrazole-pyridones are also included.

Thrombin inhibitors, formulations, and uses thereof

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin and/or kallikrein, which compounds include substituted pyrazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which diseases or disorders are amenable to treatment or prevention by the inhibition of thrombin and/or kallikrein.

Substituted pyrazole compounds as serine protease inhibitors

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

Multisubstituted aromatic compounds as serine protease inhibitors

There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Pyrazolyl-substituted pyridone compounds as serine protease inhibitors

A method and apparatus for estimating the motion of an image region (the 'center' region) from a source video frame to a target video frame. The motion estimation is locally constrained in that the estimated motion of the 'center region' is affected by the estimated motion of neighboring regions. Advantageously, this may reduce common motion matching problems such as false and ambiguous matches. In one embodiment, the locally-constrained motion estimation may be implemented by biasing an error map of the center region using error maps of the neighboring regions.

Local constraints for motion matching

A method for partitioning a molecular subset is described. The partitioning method takes into account molecular structure and its manner of storage and transmission, transformations to be applied to the molecular subset and their implementation, and constraints imposed by the implementation of the partitioning method. Using this method, a molecular subset can be stored, transmitted, and processed more efficiently. The resulting efficiency makes it possible to design and run applications which require complex molecular processing, such as rational drug discovery, virtual library design, etc.

Method and device for partitioning a molecule

The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of pools of probes, as well as methods of generating pools of probes.

Enhanced sequencing by hybridization using pools of probes

Computing units are determined for performing molecular docking calculations in parallel with the number of computing units and the width of the data paths allocated by relative complexity of operations. Data can be expected to arrive at downstream computing units as it is needed, leading to higher utilization of computing units. Computing units are hardware components that are specific to a calculation performed. For molecular docking calculations, functions of molecular subsets or of combinations of molecular subsets are calculated. Determinations include fit between molecular subsets, affinity or energy of 'fit' between molecular subsets, etc. Affinity might include inter-atomic energy, bond energy, energy of atoms immersed in a field, etc. The calculations could be used to simulate and/or estimate likelihoods of molecular interactions.

Method and apparatus for analysis of molecular configurations and combinations

A method and apparatus for analysis of molecular combinations featuring two or more molecular subsets is described. The method computes the shape complementarity of the system utilizing a basis expansion representing molecular shapes of the first and second molecular subsets in a coordinate system. The precomputed sets of translated expansion coefficients for the first molecular subset are first constructed via application of a translation operator to a reference set of expansion coefficients and then stored on a computer recordable medium for later retrieval. Then, a shape complementarity score, representing a correlation of the first and second molecular subsets, is computed via suitable application of rotation operators to both the stored translated expansion coefficients of the first molecular subset and the reference expansion coefficients for the second molecular subset over the sequence of different sampled configurations for the molecular combination.

Method and apparatus for analysis of molecular combination based on computations of shape complementarity using basis expansions

A method for the prediction of adverse cross-reactions between lead candidate biomolecules and potential reactant molecules, often biopolymers, is described. In a computational system, reactions are modeled within a suitable environment, in order to determine a reaction profile between a lead candidate molecule and a potential reactant molecule. A risk assessment is then generated for each lead based on a plurality of reaction profiles for the lead with respect to a plurality of potential reactant molecules. The method includes provisions for redesign and optimization of the lead candidate, possibly iterative in nature, in order to avoid predicted adverse cross-reactions.

Lead molecule cross-reaction prediction and optimization system

One embodiment disclosed relates to a method for encoding and decoding a video sequence in which a keyframe is used to bi-directionally predict frames in the sequence. The keyframe is coded independently of other frames in the sequence. Both a prior frame occurring before the keyframe and a subsequent frame occurring after the keyframe are predicted using data from the keyframe. Another embodiment disclosed relates to a method for allocating bits to a keyframe during video encoding. Effects of a plurality of keyframe bit allocations on quality of a predicted frame are measured. Said effects are used to determine a near optimal keyframe bit allocation.

Efficient use of keyframes in video compression

Growing community of inventors

Milpitas, CA, United States of America

David B Kita