Eli Lilly and Company

Battelle Memorial Institute

Cardinal Health 414, LLC

Revive Environmental Technology, LLC

Ic Surgical, Inc.

Arrow Group Industries, Inc.

David Arthur Holley

Jeffrey L Ellis

William Godwin Atterbury

Slawomir Winecki

Darwin Argumedo

Corrie Bennison

Joshua James

Kavitha Dasu

Joseph Casciano

Christopher Gordon Scheitlin

Lindy E Dejarme

Aaron Frank

Michael M Miller

Nathan Bryant

Dan Garbark

Doug Hendry

Chad Edward Bouton

Thomas Alan Klausing

Scott Nicholas Danhof

John P Tallarico

Eric Hassenpflug

Brian Charles Kelley

Joseph Edward Zambanini

Mehmet Husnu

Dennis Eshima

Jeffrey Taylor Stroup

John Paul Tallarico

John Tallarico

Herman P Benecke

Daniel B Garbark

James A Prescott

Keith E Brown

James B Gleeson

Keith Brown

Derrick Alcaide

Beverly Ann Piatt

Henry Padgett

Russel R Sirabian

Russell R Sirabian

James Stone

Gregory A Trees

Amy M Heintz

Thomas D Haubert

James E Dvorsky

Steven Michael Madland

John Bartholomew

Mark Lafever

Timothy Mark Blum

Jeffrey Richard Held

Michael Scott Ulrich

Peter Andrew Gaydos

David R Busick

Beverly Anne Piatt

Russell Kittel

Michael Allen Spicer

Christopher F Buurma

Daniel Duane Meek

Jeffrey L Hall

Steven M Madland

Amy Dindal

Matthew Vaughan

Christopher G Ross

Phillip A Green

Colin A Chong

Noah John Scott Lemire

Larry K Hooks, Jr

Robert Jonathan Cain

Michael Funk Chiappetta

Corrie Jo Bennison

Jeffrey Leclair Ellis

Daniel D Meek

A therapeutic agent delivery system comprises a housing. A therapeutic agent delivery assembly is carried by the housing. The therapeutic agent delivery assembly comprises a chamber having a passageway. A therapeutic agent is carried in the passageway, and a needle is in communication with the passageway. The therapeutic agent delivery assembly may be translatable relative to the housing from a stowed configuration to a deployed configuration. Actuation of a user input may translate the therapeutic agent delivery assembly from the stowed configuration to the deployed configuration. An input restraint may be rotatable relative to the housing from a first rotational configuration to a second rotational configuration. In the first rotational configuration the input restraint may inhibit actuation of the user input, and in the second rotational configuration the input restraint may permit actuation of the user input.

Devices and processes for delivery of therapeutic fluids

A therapeutic agent delivery system () includes a housing () and a drive wheel () rotatably carried by the housing. A plunger rod () may be rotatable with the drive wheel relative to the housing from a first rotational configuration to a second rotational configuration. The plunger rod may be translatable relative to the housing from a first translational configuration to a second translational configuration. A plunger restraint () may maintain the plunger rod in the first translational configuration when the plunger rod is disposed in the first rotational configuration. The plunger restraint may permit the plunger rod to translate to the second translational configuration when the plunger rod is disposed in the second rotational configuration. A needle may move from a stowed configuration to a deployed configuration by the plunger rod when the plunger rod moves from the first translational configuration to the second translational configuration.

Systems, devices, and processes for delivery of therapeutic fluids

Per- and polyfluoroalkyl substances (PFAS) are destroyed by oxidation in supercritical conditions. PFAS in water can be concentrated and prepared for destruction in a pretreatment phase. Following annihilation of the PFAS in supercritical conditions to levels below 5 parts per trillion (ppt), the water effluent can be used to recover heat, returned to sub-critical conditions, and then released back into the environment.

Destruction of PFAS via an oxidation process and apparatus suitable for transportation to contaminated sites

Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Processes and devices for delivery of fluid by chemical reaction

Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals

An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.

Autoinjector and method of injecting fluids

Devices and systems disclosed herein may include a negative pressure pump that includes a reservoir defining a lumen and a longitudinal axis, a piston, and a drive assembly comprising a spring. Motion of the spring may move the piston along the longitudinal axis of the reservoir to create a negative pressure within the reservoir. Methods of manufacturing a negative pressure pump and using a negative pressure pump to remove fluid from a target site are also described.

Negative pressure pumps and related methods

Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.

Modular cassette synthesis unit

An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.

Nozzle for handheld pulmonary aerosol delivery device

Connection apparatus for connecting frame members and panel members is provided for constructing a storage building primarily from sheet metal. The apparatus utilizes connecting members that may be made from thermoplastic or metal materials. The number of threaded fasteners and time required to assemble the storage building is reduced dramatically from that of prior designs.

Storage building and apparatus for constructing a storage building

Growing community of inventors

Lancaster, OH, United States of America

David Arthur Holley