Irm LLC

Other

Hamilton

David Archer Ellis

Yun He

Baogen Wu

Tao Jiang

Xiaohui He

Kunyong Yang

Kelli L Kuhen

Truc Ngoc Nguyen

Badry Bursulaya

Hong Liu

Beth Anaclerio

John Wityak

Xiaolin Li

Valentina Molteni

Tom Yao-Hsiang Wu

Juliet Nabakka

Ha-Soon Choi

Zhicheng Wang

Enrique Saez

David H Woodmansee

The invention provides compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1). The compounds are of the Formulae Ia, Ic, Ig and Ik: 

Azolopyrimidines as inhibitors of cannabinoid 1 activity

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).

Compounds and compositions as LXR modulators

The invention provides compounds having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein R, R, R, Rand Y are as defined in the specification; as well as pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Compounds and compositions as inhibitors of cannabinoid receptor 1 activity

The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Pyrrolidones with anti-HIV activity

The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Oxindoles with anti-HIV activity

The present invention relates to inhibition of viruses, e.g., HIV using quinolones and compounds related to quinolones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Quinolones with anti-HIV activity

A housing device for the retractable storage of a wire, cord or cable which is capable of operationally interconnecting electronic equipment, such as portable speakers and radios, while the interiorly coiled end of the wire, cord or cable remains coiled around a rotatable spool during connection. In its preferred embodiment, the housing device has a cover with connection ports therethrough. A radio connected to the connection ports becomes operationally connected with the interiorly coiled end of the wire, cord or cable through electrically conductive means integral with the spring-driven spool. The outer end of the coiled wire is then extended through an opening in the housing cover and connected to a portable speaker. The opening in the housing would be just large enough to accommodate the wire. A device larger in diameter than the wire would be attached at the near end of the exposed wire to prevent it from retracting all the way back inside the housing. After disconnection from the speaker, a light tug on the outer end of the coiled wire engages the spring-activated spool to retract the outer end back into the housing.

Retractable speaker wire

Growing community of inventors

San Diego, CA, United States of America

David Archer Ellis