Astec International Limited

Oxford University Innovation Limited

David Anthony Smith

Helga Refsum

Fredrik Jerneren

Carl K Sawtell

Marc E Dagan

The present invention provides a combined therapy comprising the use of one or more omega-3 fatty acids and one or more B vitamins and for treating cognitive impairment, such cognitive impairment disorders include, especially but not exclusively, Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). The present invention also provides a treatment for individuals suffering from cognitive impairment disorders that occur as a result of brain or cerebral atrophy, the invention includes inter alia methods of treating and/or reducing progression of brain atrophy and pharmaceutical compositions and nutritional supplements therefor.

Combination therapy comprising an omega-3 fatty acid, a folate species and a vitamin B12 species

The present invention provides a combined therapy comprising the use of one or more omega-3 fatty acids and one or more B vitamins and for treating cognitive impairment, such cognitive impairment disorders include, especially but not exclusively, Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). The present invention also provides a treatment for individuals suffering from cognitive impairment disorders that occur as a result of brain or cerebral atrophy, the invention includes inter alma methods of treating and/or reducing progression of brain atrophy and pharmaceutical compositions and nutritional supplements therefor.

A circuit for controlling the switching behavior of a field effect transistor (FET) or other power switch in a power supply or converter. The circuit includes an adaptive feedback loop which controls the switching operation of the FET through application of a gate drive signal to the device. The circuit is designed to turn the switching device on or off at the optimum time to reduce the stress and power losses associated with the switching action. The circuit includes a capacitor connected to the FET switch drain to sense the falling voltage across the switch. The adaptive gate drive circuit holds the FET switch off until the drain voltage sensed by the capacitor stops decreasing. At this time, the FET switch voltage is either zero (zero-voltage switching) or has reached the minimum value of its resonant ring (low-voltage switching). The gate drive circuit then turns the FET switch on, initiating a new cycle of charging up the inductor or primary transformer winding which is part of the power supply or converter. The present invention, thus acts, to minimize switching stress and power loss during the switching cycle.

Adaptive drive circuit for zero-voltage and low-voltage switches

In a power converter whose power is supplied by an input power source, a circuit is disclosed for efficiently clamping the peak reset voltage across a primary switch of the power converter and for recycling the energy stored in the clamp during the OFF period of the switch back to the input power source via a second converter through the operation of a plurality of switching transistors in the second converter. The reset energy of the power transformer in the power converter can also be coupled to an auxiliary power circuit via a winding of a transformer in the second converter. The second converter can thus provide auxiliary or stand-by power to maintain the operation of critical system circuits, when the power converter is turned off, e.g., to conserve power, such as in the sleep mode of a portable PC.

Circuit for efficiently clamping a power converter's reset voltage and for providing auxiliary power

A transformer with a plurality of secondary windings with substantially similar coupling to the primary winding is used to facilitate synchronous rectification of the output by a rectifier attached to each secondary winding, reducing power losses compared to conventional power supplies with a single secondary winding coupled to a single rectifier. In a preferred embodiment, the transformer comprises at least two primary windings, with each primary winding coupled to at least two secondary windings.

Current sharing transformer circuit for power converters

An improved low profile transformer is disclosed. The transformer has desirable characteristics for switch mode power supplies such as minimum high frequency resistance, improved coupling of primary and secondary windings, and reduced eddy current losses. The transformer has a primary winding comprised of an insulated conducting foil that is folded into a staircase-shaped winding. One or more secondary winding segments comprised of U-shaped conducting sheets are interleaved with the primary winding to form a minimally separated primary and secondary winding. The windings are substantially surrounded by an E-shaped magnetic core to facilitate the magnetic coupling of the windings.

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Cumnor Hill, United Kingdom

David Anthony Smith