Pfizer Corporation

Agouron Pharmaceuticals, Inc.

Other

David Anthony Price

Paul Alan Glossop

Alan Daniel Brown

Mark Edward Bunnage

Kim James

Charlotte Alice Louise Lane

Anthony Wood

Manoussos Perros

Blanda Luzia Christa Stammen

Paul Anthony Stupple

Matthew Duncan Selby

Lyn Howard Jones

Charles Eric Mowbray

Nicholas Murray Thomson

Ian Brian Moses

Russel Andrew Lewthwaite

Russell Andrew Lewthwaite

Martin Paul Edwards

Duncan Robert Armour

David Simon Millan

Graham Lunn

Blanda Luzia Stammen

Charlotte Alice Lane

This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

Glucocorticoid receptor agonists

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodeficiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

Pyrazole derivatives

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

Sulfonamide derivatives for the treatment of diseases

Compounds useful for the treatment of diseases

Amine derivatives for the treatment of asthma and COPD

The present invention provides compounds of the formula: 

Tropane derivatives useful in therapy

Formamide derivatives for the treatment of diseases

Compounds for the treatment of diseases

This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

The present invention provides compounds of the formula: wherein Ris Ccycloalkyl optionally substituted by one or more fluorine atoms, or Calkyl optionally substituted by one or more fluorine atoms, or Ccycloalkylmethyl optionally ring-substituted by one or more fluorine atoms; and

Compounds of Formula 1[R&#x3b1;]&#x2212;[R&#x3b2;]&#x2212;[R&#x3b3;]&#x2212;[R&#x3b4;] &#x2003;&#x2003;(I)which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and methods of treatment using these compounds.

CCR5 modulators

Growing community of inventors

Sandwich, United Kingdom

David Anthony Price