University Health Network

Elekta Ab (Publ)

Koninklijke Philips Corporation N.v.

Other

Institut National D'optique

William Beaumont Hospital

Elekta Ab

David Anthony Jaffray

Jeffrey H Siewerdsen

Kevin J Brown

Christine Allen

Jinzi Zheng

Mohammad Khairul Islam

Jan-Jakob Sonke

Marcel Van Herk

Robert Weersink

Michael B Sharpe

Arash Zarrine-Afsar

Bernhard Dieter Norrlinger

Young-Bin Cho

Alexandra Rink

Robert K Heaton

John Cho

Andrew Hope

Gregory Jason Perkins

Raymond Matthew Reilly

Gregory Bootsma

Heinrich Schulz

Vladimir Pekar

Michael Kaus

Torbjoern Vik

Per Carlsson

Serge Caron

Håkan Nordström

John W Wong

Jonas Anders Adler

Marco Carlone

Ozzy Mermut

André Croteau

Thomas G Purdie

Daniel Letourneau

Francois Roy-Moisan

Bradly G Wouters

Sean Alexander Graham

Kevin John Brown

Teodor Marius Stanescu

Lambert Zijp

Michael Woolman

Markus Eriksson

Mark William Taylor

I Alex Vitkin

Marcus Hennix

Edward Taylor

Douglas J Moseley

Mark Ruschin

Monique Van Prooijen

Ivan Wai Tong Yeung

Jason Smale

Duncan M Galbraith

Bjorn Nutti

Alessandra Tata

Jeremy D P Hoisak

Frank Verhaegen

Steven Joe Bartolac

Jimmy Qiu

Jeff Siewerdsen

Aidin Kashigar

Michael Daly

Jonathon Eubank

Yonghai Sun

Tze-wei Yeow

François Roy-Moisan

Alexander Vitkin

Douglas Moseley

Ryan Steven Elliott

Alexander Ralph Lino Jaffray

Bernhard D Norrlinger

Mohammad K Islam

Jeffrey Siewerdsen

Andre Croteau

Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (v) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced&#x2014;that is, trapping rates kare only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate kand TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate k, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

System, methods, and devices for calculating hypoxic fraction and equilibration rate of small molecular weight tracers using dynamic imaging

Various embodiments are described herein for sensors that may be used to measure radiation from radiation generating device. The sensors may use a collector plate electrode with first and second collection regions having shapes that are inversely related with one another to provide ion chambers with varying sample volumes along a substantial portion of the first and second collection regions which provides virtual spatial sensitivity during use.

Sensors with virtual spatial sensitivity for monitoring a radiation generating device

Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.

System and method for optimized mass spectrometry analysis

The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.

Multimodal CT/optical agents

A Radio-Therapy (RT) system includes an integrated radiation source and a Magnetic Resonance Imaging (MRI) system that implements a method for providing a variable imaging Field Of View (FOV). The FOV can be tailored for various RT-specific applications such as, but not limited to, patient setup verification and real-time tumor tracking, for example, as well as for various imaging volumes of interest.

Radiotherapy system integrating a radiation source with a magnetic resonance imaging apparatus with movable magnet components

Embodiments disclose a method performed by at least one processor for processing a plurality of x-ray projection images of a subject, the method comprising a plurality of operations including reconstructing the projection images to yield a volume reconstruction; segmenting the reconstructed volume by assigning a material type to each voxel; estimating a first set of scatter images corresponding to a subset of the projection images by calculating probabilistic predictions of interactions of x-rays with the subject and applying a low pass spatial filter to the scatter images; estimating a second set of scatter images corresponding to projection images not included in the subset, based on the first set of scatter images; and subtracting, for each projection image, the corresponding scatter image to yield a corrected projection image. Applying the plurality of operations of the method in an iterative process on graphics-processor-quality computational hardware enables real-time scatter correction and reconstruction of CT volume images.

Target-specific dose and scatter estimation in CT images

Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

System and method for enhanced mass spectrometry imaging

An apparatus for high resolution positron emission tomography (PET) imaging. The apparatus includes at least a first detector and a second detector arranged to detect gamma rays traveling from a target area, the first detector and the second detector being a detector pair. There is at least one collimator for filtering gamma rays reaching the first and second detectors. The collimator defines respective passages filtering gamma rays reaching the respective first and second detectors, the passages being defined to filter for only gamma ray pairs traveling from the target area at a predetermined range of angles with respect to each other, the predetermined range of angles being in the range of 180&#xb0;-&#x3b8;, where &#x3b8;is less than 1&#xb0; and greater than 0&#xb0;.

Apparatus for high resolution PET imaging

A method and imaging system for operating imaging computed tomography using at least one radiation source and at least one detector to generate an image of an object. The method includes: defining desired image characteristics; and performing calculations to determine the pattern of fluence to be applied by the at least one radiation source, to generate said desired image quality or characteristics. Then, the at least one radiation source is modulated, to generate the intended pattern of fluence between the beam source and the object to be imaged. The desired image characteristics can provide at least one of: desired image quality in at least one defined region of interest; and at least one desired distribution of said image quality.

Optimized aperture selection imaging computed tomography system and method

There is provided signal modifying compositions for medical imaging comprising a carrier and signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect of the signal modifying agents that enables prolonged contrast imaging without significant depletion of the signal modifying agent from the carrier. The carriers of the present invention are lipid based or polymer based the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.

Compositions and methods for multimodal imaging

Methods and systems for visualization of 3D parametric data in a 2D image. The set of 3D parametric data includes a plurality of voxels in 3D space each associated with at least one parametric value, and the set of 2D image data includes information about a known camera position and a known camera orientation at which the 2D image was obtained. A graphical representation is generated of the parametric values of the voxels corresponding to a viewing surface in 3D space. A virtual 2D view of the viewing surface is determined. The 2D image is displayed registered with the graphical representation of the parametric values of the voxels corresponding to the virtual 2D view.

Methods and systems for visualization of 3D parametric data during 2D imaging

A method, computer program product and processor for quantitatively registering a 2D endoscopic ROI in a 3D volumetric imaging dataset. An endoscopic dataset and a volumetric imaging are registered to a common coordinate system. A 2D endoscopic ROI is generated within the endoscopic imaging dataset. A 3D surface ROI is generated within the volumetric imaging dataset corresponding to the 2D endoscopic ROI, based on a projection of the 2D endoscopic ROI to the registered common coordinate system.

Quantitative endoscopy

A system and method for commissioning of a beam model for a three dimensional radiation therapy treatment planning system is described. The system includes an intensity modulated radiotherapy (IMRT) unit for generating a two dimensional intensity modulated beam pattern, a two dimensional diode array for detecting a two dimensional dose map for the beam pattern, and a processor configured to execute instructions for iteratively adjusting one or more parameters for the beam model, in order to increase agreement between the detected dose map and a calculated dose map calculated using the beam model.

System and method for commissioning of a beam model for a three dimensional radiation therapy treatment planning system

Various embodiments are described herein for nanostructure field emission cathode structures and methods of making these structures. These structures generally comprise an electrode field emitter comprising a resistive layer having a first surface, a connection pad having a first surface disposed adjacent to the first surface of the resistive layer, and a nanostructure element for emitting electrons in use, the nanostructure element being disposed adjacent to a second surface of the connection pad that is opposite the first surface of the connection pad. Some embodiments also include a coaxial gate electrode that is disposed about the nanostructure element.

Nanostructure field emission cathode structure and method for making

A fiber optic dosimeter probe for sensing radiation dose including an optical fiber having a free end and a sensitive end, a window having a sensitive side and a rear side; a radiation sensitive layer between the sensitive end of the optical fiber and a sensitive side of the window, the radiation sensitive layer being made of a material having an optical property that changes with absorbed radiation dose, an amount of the material corresponding to a predetermined sensitivity to radiation; wherein the window and the optical fiber have a near water equivalent interaction with radiation and are MR compatible.

Fiber optic radiochromic dosimeter probe and method to make the same

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Etobicoke, Canada

David Anthony Jaffray