Syngenta Crop Protection, Inc.

Syngenta Corporation

Syngenta Participations Ag

David Anthony Jackson

Martin Charles Bowden

Andrew Edmunds

Brian David Gott

James Peter Muxworthy

Alexandre Christian Saint-Dizier

Ben Brockbank

Iacob Eremia Gutu

Mark Robert Sykes

George Robert Hodges

Florian Schleth

David Drouard

Devender Singh Negi

Werner Pfaff

Iacob Eremia Gutsu

The present invention relates to novel processes for the production of compounds of formula wherein Hal and Hal' are independently selected from Cl and F, and Ris selected from Cl, F and H.

Processes for the preparation of pyrazoles

The present invention relates to a continuous process for producing a haloalkenone ether of the Formula (I) wherein Ris C-Chaloalkyl, Ris a C-Calkyl or phenyl, the process comprising:&#x2014;(i) reacting, in a first continuous stirred tank reactor comprising a solvent, a halide of Formula (II) wherein Ris as previously defined and Ris halogen, with a vinyl ether of Formula (III) wherein Ris as previously defined, to form an intermediate compound of Formula (IV), wherein the concentration of the vinyl ether of Formula (III) in the reaction mass is 15% or less w/w; and (ii) transferring the reaction mass from the first continuous stirred tank reactor into a subsequent continuous stirred tank reactor, wherein the conditions within the subsequent reactor permit the elimination of hydrogen halide (HR) from the intermediate compound of Formula (IV) to provide the haloalkenone ether of Formula (I). 

Chemical process for the production of haloalkenone ethers

The invention relates to a process for the preparation of intermediates useful in the preparation of fungicidally active phenylpropargylether derivatives. The process involves coupling of carboxylic acid with an amine in (a) the absence of a catalyst; (b) the presence of a boronic acid catalyst. 

Processes for the preparation of amides

The present invention relates to novel processes for the production of compounds of formula (I) wherein Hal and Hal' are independently selected from Cl and F, and Ris selected from Cl, F and H. 

The invention relates to a process for the preparation of fungicidally active compounds such as tricyclic amine derivatives (I). The process involves coupling of a carboxylic 5 acid e.g. a compound of formula (II) with an aniline, e.g. a compound of formula (III) in the presence of a boronic acid catalystor an antimony catalyst (II)(III)(I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Het are defined in the specification. 

Process for the preparation of amides

The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claim, by reacting a compound of formula (II), with a bromine or chlorine source to form a compound of formula (III), wherein X is chlorine or bromine; reacting that compound with water to form the compound of formula (IV), converting that compound, using a compound of formula (V), wherein Mis the hydrogen cation or an alkali metal ion, alkaline earth metal ion or ammonium ion, into the compound of formula (VI), and treating that compound with a cyanide source in the presence of a base. 

Process for the production of cyclic diketones

The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claimby reacting a compound of formula (II), either with a chlorination or bromination agent or with a compound of formula (III) CI&#x2014;SOR, Rbeing C-Calkyl, C-Chaloalkyl, phenyl or C-Calkyl-substituted phenyl, to form the compound of formula (IV), reacting the compound of formula (IV) with a compound of formula (V) M-O&#x2014;C(O)&#x2014;Y wherein Y is as defined above and Mis the hydrogen cation or an alkali metal ion, alkaline earth metal ion or ammonium ion, to form the compound of formula (VI) and treating that compound with a cyanide source in the presence of a base. 

The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim, by reaction of a compound of formula (II) wherein Ris C-Calkyl or C-Ccycloalkyl and Rand Rare as defined for formula (I), with a compound of formula (III) wherein R, R, Rand X, are as defined for formula (I) in claim, in an inert solvent in the presence of a proton source. 

Process for the production of substituted nicotinic acid esters

The present invention relates to a compound of the general formula: wherein Ris a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and wherein Ris any group which can be transesterified to form a methyl ester. The present invention is also directed to a process of preparing said compound.

Process for the preparation of azoxystrobin and analogues thereof

A process for the preparation of a compound of the general formula (I): wherein Ris a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and Ris any group which can be transesterified to form a methyl ester, which comprises treating a compound of general formula (II): wherein Rand Rhave the meanings given above, with a formylating agent and subsequently treating the formylated product with a methylating agent 

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Muenchwilen, Switzerland

David Anthony Jackson