University College Cardiff Consultants Limited

Protasis Corporation

Q Chip Limited

David Anthony Barrow

Joseph John Cefai

David M Strand

William Terence Coakley

Oliver Kieran Castell

Jeremy John Hawkes

Divesh Baxani

Nicola Harries

Tyrone Gwyn Jones

Kostas Bouris

Graham Sparey-Taylor

Oliver Castell

The invention relates to an artificial cell system comprising at least one droplet-interface bilayer (DIB) encased within a shell; a suspension comprising same; and a method and a device for the manufacture of same.

Artificial cells

Fluid-handling methods and devices for ultrasonic manipulation of fluid-borne particles comprise a fluid-handling manifold and an ultrasonic particle manipulator defining an ultrasonic cavity within the manifold. Fluid-borne particles introduced into the manifold are manipulated by controlling ultrasonic standing waves at the ultrasonic cavity. Cavities having non-uniform configurations, asymmetric standing waves and/or multiple ultrasonic cavities within the manifold are operative to control the movement of the fluid-borne particles, optionally including collecting and holding such particles, transferring particles through an intersection from one channel to another, etc. Solid phase extraction (SPE) particles, biological particles and other fluid-borne particles can be manipulated within the fluid-handling manifold.

Method and device for ultrasonically manipulating particles within a fluid

A microfluidic device comprises first and second inlet passages () for respective immiscible fluids, these inlet passages merging into a third passage () along which the two fluids flow under parallel laminar flow conditions, the third passage being formed with a constriction or other discontinuity () causing the two fluids to form into a flow of alternate segments.

Microfluidic device and methods for construction and application

Fluid processing apparatus comprises a fluid-handling manifold comprising a manifold body having at least a first fluid duct and a second fluid duct. The first and second fluid ducts are in fluid communication with each other at a microfluidic junction of the fluid-handling manifold. The manifold body further comprises a transducer operative to generate ultrasonic acoustic traveling wave radiation into fluid in the microfluidic junction from an active surface toward a non-reflective boundary of the microfluidic junction. The microfluidic junction is operative to pass fluid received from the first and second duct, with micro-mixing effected by the traveling wave radiated into the junction during the fluid flow.

Fluid-handling apparatus and methods

An apparatus which manipulates particles suspended in a fluid includes a duct for the flow of the fluid in which the particles are suspended, and a mechanism for establishing an acoustic standing wave field across the width of the duct, the duct being formed with an expansion in width downstream of the standing wave field. In use, the particles in the fluid are displaced into a series of parallel bands by the acoustic standing wave field. The particles remain in these bands as the fluid flows downstream from the section in which the standing wave field is present. When the fluid reaches the expansion of the duct, the stream of fluid expands accordingly in width and, in so doing, the bands of particles are spread further apart, so increasing the spacing between adjacent bands. The bands can then be observed or separated from the duct.

Particle manipulation

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Cardiff, United Kingdom

David Anthony Barrow