Other

Cancer Research Technology Limited

Iceni Diagnostics Limited

David Andrew Russell

William Guy Love

Michael J Cook

Martin Rejzek

Maria Jose Marin Altaba

Rob Field

Abdul Rashid

Duncan Christopher Hone

The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus&#x2014;for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

Virus detection

The present invention relates to self-assembly of a photosensitizer on a nanoparticle. The invention also provides methods for production of functionalized (eg. stabilized) nanoparticles. The nanoparticles may be used in Photodynamic Therapy (PDT). The invention can provide, for example, self-assembled phthalocyanine monolayers (SAMs), wherein the monolayer is formed on a metallic nanoparticle. The term 'metallic' as used herein refers to metals, metal oxides and other metal-containing compositions. According to the invention a functionalized nanoparticle comprises:

Photosensitizer functionalised nanoparticles

There is provided a compound of formula (I), wherein R , R , R , R , R , R , R , R , R , X, Y , Y , Y , Z, M, A-B and C-D have meanings given in the description, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Compositions, apparatus and methods of treatment of a medical condition for which a photodynamic compound is indicated are also disclosed.

Porphyrin derivatives their use in photodynamic therapy and medical devices containing them

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Norfolk, United Kingdom

David Andrew Russell