Abbvie Inc.

David Andrew Kinsman

Anil Vasudevan

Michael M Friedman

Eric C Breinlinger

Noel S Wilson

Justin D Dietrich

Kelly Mullen

Augustine Osuma

Andrew Burchat

David Ihle

Michael Z Hoemann

Maria A Argiriadi

Kevin Patrick Cusack

James Patrick Stambuli

Sami Osman

Euan Fordyce

Steve St Gallay

Ciaran O'Reilly

Hannah Dexter

Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

Nicotinamide RIPK1 inhibitors

The disclosure provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the disclosure are useful for treating immunological and oncological conditions.

Indazolones as modulators of TNF signaling

Growing community of inventors

Worcester, MA, United States of America

David Andrew Kinsman