Wisconsin Alumni Research Foundation

Yale University

University of Cincinnati

Cincinnati Children's Hospital Medical Center

David Andes

Timothy Bugni

Douglas Braun

Kenneth D Greis

Margaret K Hostetter

Thomas Wyche

Long Lu

Julianne Vernadette Green

Alexey Porollo

Kris I Orsborn

Khoon Ghee Queenie Tan

Shaoqin Gong

Cameron Robert Currie

Fan Zhang

Mingzhou Ye

Miao Zhao

Monica Tallarico Pupo

Humberto Enrique Ortega Dominguez

Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.

Dual-responsive nanoparticles for enhanced antibacterial efficacy

Turbinmicin, an isolated compound of Formula (I) or IA is provided. Turbinomycin compounds of Formula (II) or (IIA) are also provided. A compound isolated from a bacterial species from the sea squirt,, and having a chemical formula of CHNOis also provided. Compositions including turbinmicin and turbinmicin compounds, such as pharmaceutical compositions including effective amounts of turbinmicin or turbinomicing compounds for treating fungal infections such asand, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with turbinmicin, turbinmicin compounds and compositions thereof are disclosed.

Turbinmicin compounds, compositions and uses thereof

An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated fromand having a chemical formula of CHClNOSor CHBrNOSis also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such asare also disclosed.

Forazolines, compositions thereof and uses thereof

Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insectand having a chemical formula of CHOis also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such asand, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.

Cyphomycin, compositions and uses thereof

Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such asspecies and/orspecies.

Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices

Growing community of inventors

Madison, WI, United States of America

David Andes