The General Hospital Corporation

The Broad Institute, Inc.

Instituto Carlos Slim De La Salud, A.c.

University of Minnesota

Whitehead Institute for Biomedical Research

David Altshuler

Amedeo Vetere

Sean M Burns

Eric S Lander

Robert Royal Graham

Timothy W Behrens

The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.

Propeptide-luciferase fusion proteins and methods of use thereof

Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.

IRF-5 haplotypes in systemic lupus erythematosus

The present invention provides a computer method and apparatus for detecting mutations in DNA fragments. Specifically, percent acetonitrile and threshold temperature, for use in the denaturing high performance liquid chromatography method of separating DNA fragments, are determined. In a preferred embodiment, the present invention serves as a preprocessor to the DHPLC system described in the cited art.

Computer method and apparatus for analyzing mutations in DNA

Growing community of inventors

Brookline, MA, United States of America

David Altshuler