Lyndra Therapeutics, Inc.

David Altreuter

Nupura Bhise

James I Wright

Stephen E Zale

Susan C Low

Andrew Bellinger

Tyler Grant

Colin R Gardner

Rosemary Lynn Kanasty

Jung Hoon Yang

Megan Bishoff

Bennett Carter

Erick Peeke

Sonia Holar

Marlene Schwarz

Provided are gastric residence dosage forms comprising: a gastric residence system in a folded configuration; a capsule encapsulating the gastric residence system in a folded configuration; and a coating on the capsule, wherein the gastric residence dosage form is configured to release the gastric residence system in a stomach of a patient, allowing the gastric residence system to assume an open configuration. The coating on the capsule includes a polymer, an anti-tacking agent, and/or a hydration aid.

Capsules and capsule coatings for gastric residence dosage forms

The invention provides gastric residence systems, or components of gastric residence system such as segments or elongate members of gastric residence systems, with release rate-modulating films and methods for making and using such systems. The release rate-modulating films provide good control over release of agents (such as therapeutic, diagnostic, or nutritional agents) present in the gastric residence system. The films also permit higher drug loading in the gastric residence systems and components of gastric residence systems while maintaining good control over release of agents. Some embodiments of the films can provide resistance against burst release of agent upon exposure to alcohol.

Gastric residence systems with release rate-modulating films

Growing community of inventors

Wayland, MA, United States of America

David Altreuter