Colorado State University Research Foundation

David Alois Prawel

Susan P James

Ketul C Popat

Richard L Koch

Lakshmi Prasad Dasi

Travis S Bailey

Jackson T Lewis

Harold Dean, Iv

Marcio H Forleo

Nicole R Lewis

Harold Dean Iv

Implementations described and claimed herein provide systems and methods for manufacturing customized cardiovascular devices. In one implementation, patient cardiovascular data for a patient is received at a controller. The patient cardiovascular data is captured using a patient interface. A printing profile for a cardiovascular medical device is received at the controller. A patient specific three-dimensional model of the cardiovascular medical device customized for the patient using the patient cardiovascular data and the printing profile is generated. The patient specific three-dimensional model of the cardiovascular medical device is sliced into a plurality of outlines using the controller. Print instructions based on the plurality of outlines are generated using the controller. A polymeric material is manipulated according to the print instructions into a customized polymeric cardiovascular medical device for the patient. The customized polymeric cardiovascular medical device includes at least one micro-geometry.

Systems and methods for manufacturing customized medical devices

Provided herein is a polymeric material comprising a polymer host; and a guest molecule comprising a glycosaminoglycan; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. In some embodiments, the polymer host comprises a silicone-based polymer. In other embodiments, the glycosaminoglycan is chosen from hyaluronic acid and derivatives thereof.

Synthetic polymeric materials and devices thereof

Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts.

Glycosaminoglycan and synthetic polymer material for blood-contacting applications

Growing community of inventors

Loveland, CO, United States of America

David Alois Prawel