Brookhaven Science Associates, Lcc

Assoicated Universties, Inc.

David Alexoff

Richard A Ferrieri

Jacob Matthew Hooker

Sung Won Kim

Dohyun Kim

David J Schlyer

A method for providingC-labeled cyanides fromC labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O, whereinC labeled oxides are reduced with Hin the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95%CH, theCHis then combined with an excess of NHin a carrier/reaction stream flowing at an accelerated velocity and the combinedCH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900&#xb0; C., whereby a product stream comprising at least about 60% HCN is provided in less than 10 minutes from retrieval of theC labeled oxide.

C-11 cyanide production system

A method for providingC-labeled cyanides fromC labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing Ois provided, whereinC labeled oxides are reduced with Hin the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95%CH, theCHis then combined with an excess of NHin a carrier/reaction stream flowing at an accelerated velocity and the combinedCH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 &#xb0; C., whereby a product stream comprising at least about 60%HCN is provided in less than 10 minutes from retrieval of theC labeled oxide.

A handling and processing apparatus for preparing Oxygen-15 labeled water (H.sub.2 [.sup.15 O]) in injectable form for use in Positron Emission Tomography from preferably H.sub.2 [.sup.15 O] produced by irradiating a flowing gas target of nitrogen and hydrogen. The apparatus includes a collector for receiving and directing a gas containing H.sub.2 [.sup.15 O] gas and impurities, mainly ammonia (NH.sub.3) gas into sterile water to trap the H.sub.2 [.sup.15 O] and form ammonium (NH.sub.4.sup.+) in the sterile water. A device for displacing the sterile water containing H.sub.2 [.sup.15 O] and NH.sub.4.sup.+ through a cation resin removes NH.sub.4.sup.+ from the sterile water. A device for combining the sterile water containing H.sub.2 [.sup.15 O] with a saline solution produces an injectable solution. Preferably, the apparatus includes a device for delivering the solution to a syringe for injection into a patient. Also, disclosed is a method for preparing H.sub.2 [.sup.15 O] in injectable form for use in Positron Emission Tomography in which the method neither requires isotopic exchange reaction nor application of high temperature.

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Westhampton, NY, United States of America

David Alexoff