Talis Biomedical Corporation

David Alexander Rolfe

Thomas Henry Cauley, Iii

John Dixon

Michael John McAdams

Hédia Maamar

David Glade

Sayeed Andeshmand

Dzam-Si Jesse Ng

Marc Valer Serra

Thomas H Iii Cauley

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Diagnostic system

This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.

Magnetic mixing apparatus

This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.

Vented converging capillary biological sample port and reservoir

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San Francisco, CA, United States of America

David Alexander Rolfe