Thomas Jefferson University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Boehringer Ingelheim Animal Health USA Inc.

David Abraham

Renato L Baserga

Mariana Resnicoff

David W Andrews

Thomas B Nutman

John Matthew Harrington

Jessica Hess

Brenda A Bondesen

The polynucleotide encoding the SSIR gene from the nematodeis provided, along with the polypeptide encoded by the SSIR gene. It was found that when mice were immunized with the SSIR polypeptide vaccine, it provided immunity to mice which were implanted withL3 implants. Methods for making the SSIR protein, recombinant vectors encoding the SSIR gene, a vaccine made from the SSIR protein, and methods of use are also provided.

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A method of inducing resistance to or regression of tumor growth comprising placing tumor cells in culture in vitro or ex vivo supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a human for a therapeutically effective time, thereby inducing resistance to or regression of tumor growth.

Treatment of tumors with oligonucleotides directed to insulin-like growth factor-I receptors (IGF-IR)

A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a diffusion chamber, thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth. The pro-apoptotic agents include nucleic acid molecules, proteins or peptides, non-proteins or non-polynucleotide compounds, and a physical conditions.

Method of inducing resistance to tumor growth

A method of inducing resistance to tumor growth comprising placing tumor cells in culture supplemented with an agent in a diffusion chamber thereby producing a cell-containing chamber, inserting the chamber into a mammal for a therapeutically effective time, thereby inducing resistance to tumor growth.

Growing community of inventors

Wynnewood, PA, United States of America

David Abraham