Danisco US Inc.

Genencor International, Inc.

The Procter Gamble Company

Genencor, Inc.

Genecor International, Inc.

The Goodyear & Tire Rubber Company

Genentech, Inc.

University of Toronto

Dansico US Inc.

Danisco US Inc., Genencor Division

David Aaron Estell

Richard Ray Bott

Ayrookaran J Poulose

Scott Douglas Power

James T Kellis, Jr

Luis Gustavo Cascao-Pereira

Frits Goedegebuur

Sina Pricelius

Andrew Shaw

Brian Frederick Schmidt

James A Wells

Robert Mark Caldwell

Katherine D Collier

Lilia Maria Babe

Jian Yao

Fiona A Harding

Thomas P Graycar

Hiroshi Oh

Marc Kolkman

Philip Frank Souter

Wolfgang Aehle

Neelam S Amin

Harm Jan Mulder

Eugene Steven Sadlowski

Brian C Cunningham

Thijs Kaper

Glenn Steven Ward

Melodie Estabrook

Brian E Jones

Christopher James Murray

Anthony G Day

Huaming Wang

Eugenio Ferrari

Chris Leeflang

Anita Van Kimmenade

Eva Maria Perez-Prat Vinuesa

Benjamin S Bower

Edmund A Larenas

Derek H Wells

Bradley R Kelemen

David Richard Light

Mark S Dennis

Robert A Lazarus

Walter Weyler

Joshua Roy Basler

Gudrun Vogtentanz

Louise Wallace

Sang-Kyu Lee

Viktor Alekseyev

Ronaldus W J Hommes

Alexander Pisarchik

Grant C Ganshaw

Hans De Nobel

Katherine Augustyn

Bryan P Fox

Jeffrey V Miller

Luis G Cascao-pereira

Marc Anton Bernhard Kolkman

Daniel Esteban Torres-Pazmino

Ronaldus Wilhelmus Joannes Hommes

Sandra W Ramer

William Albert Cuevas

Yiyou Chen

Wei Liu

Sander Van Stigt Thans

Miles Christopher Scotcher

Amr R Toppozada

Daniel Esteban Torres Pazmino

Wilhelmus A H Van Der Kley

Leonardus P M Van Marrewijk

David Marquez

Zachary Quinn Beck

Slavko Kralj

Igor Nikolaev

Rie Mejldal

Mats Sandgren

Michelle Jackson

Christopher Lee Rife

Elizabeth Ellen Sikorski

Amy D Liu

Harm Mulder

Euan John Magennis

Michael Stoner

Roopa Santosh Ghirnikar

Edward M Concar

David John Tarbit

Pilar Tijerina

Neeraj Pandey

Karl John Sanford

Michael Jay Pepsin

Christian G Paech

William H Rastetter

Dennis J Henner

Carol A Requadt

John Bryan Jones

Benjamin G Davis

Johannes Franciscus Thomas Van Lieshout

Lydia Dankmeyer

Casper Willem Vroemen

Regina Chin

The present invention provides variant subtilisins and compositions comprising at least one variant subtilisin set forth herein, as well as methods for using these variants and compositions. In some embodiments, the present invention provides variant subtilisins suitable for laundry cleaning applications.

Compositions and methods comprising variant microbial proteases

Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.

Subtilisin variants

This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN' subtilisin and subtilisin derived from, by substitution, insertion and/or deletion of one or more of the parent enzymes' amino acids.

Fabric and home care products with cold water protease

Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

Variant maltohexaose-forming α-amylase variants

The present disclosure provides AprL-clade protease enzymes, including variant AprL-clade protease enzymes, nucleic acids encoding same, and compositions and methods related to the production and use thereof, including an AprL-clade variant subtilisin enzyme that has improved stability and/or soil removal compared to a parent AprL-clade subtilisin enzyme.

AprL-clade protease variants and uses thereof

The present invention provides protease variants comprising three amino acid substitutions selected from X101N, X128S, and X217Q, compositions comprising such protease variants, and methods of using such protease variants and compositions.

Compositions and methods comprising protease variants

Disclosed herein are cellulase variants, or active fragments thereof, and polynucleotides encoding same, where the cellulase variants, or active fragments thereof, have endoglucanase activity. Also disclosed herein are compositions comprising the cellulase variants, or active fragments thereof; vectors and/or host cells comprising the polynucleotides encoding the cellulase variants, or active fragments thereof; and methods for making and/or using the cellulase variants, or active fragments thereof and/or compositions containing same; where the cellulase variants, or active fragments thereof, have endoglucanase activity.

Polypeptides with endoglucanase activity and uses thereof

Protease variants and uses thereof

Disclosed herein is one or more subtilisin variant useful for cleaning applications and in methods of cleaning. One embodiment is directed to one or more subtilisin variant, including one or moresp. subtilisin polypeptide variant, and one or more cleaning composition comprising one or more such variant.

The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained fromsp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from. In still further preferred embodiments, the neutral metalloprotease is a variant of theneutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the theneutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.

Use and production of storage-stable neutral metalloprotease

Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.

Variant maltohexaose-forming alpha-amylase variants

A phosphate-free automatic dishwashing cleaning composition comprising i) a protease wherein the protease is a variant having at least 60% identity with the amino acid sequence of SEQ ID NO:1 and comprising at least one amino acid substitution (using the SEQ ID NO: 1 numbering) selected from the group consisting of X54T; X126A, D, G, V, E, K, I; X127E, S, T, A, P, G, C; and X128E, C, T, D, P, G, L, Y, N; and ii) from 10 to 50% by weight of the composition of a complexing agent system comprising from 0 to less than 30% by weight of the composition of citric acid.

Phosphate-free automatic dishwashing detergent compositions having a protease and a complexing agent

Growing community of inventors

San Mateo, CA, United States of America

David Aaron Estell