Pharm-eco Laboratories, Inc.

Johnson Matthey Pharmaceutical Materials, Inc.

Pharma-eco Laboratories, Inc.

David A Swanson

Adel M Moussa

Salah A Zahr

Richard L Gabriel

Luning Han

Yesh P Sachdeva

Jurjus Jurayj

Changhua Liu

Brittany La

Sharon Fitzhenry

The present invention relates to a method of preparing enantiomers and diastereomers of a 2&prime;,3&prime;-dideoxy-5-fluoro-3&prime;thiocytadine (FTC) or a derivative thereof as represented by the structural formula (I), wherein R is H, a substituted or unsubstituted organic acid radical, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted heteroarakyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstitued cycloalkylalkyl group, a substituted or unsubstituted heterocycloalkylalkyl group, a sugar or a protecting group.

Methods of separating FTC isomers and derivatives thereof

An enzyme is immobilized on a solid support and can react selectively with one enantiomer in an enantiomeric mixture. A methods of using the enzyme immobilized solid support in conjunct with a separating means to separate enantiomeric mixtures is described. An apparatus for separating an enantiomeric mixture using an enzyme immobilized on a solid support is also described.

Enzyme activated supports for enantiomeric separations

Synthesis of nitroalcohol diastereomers

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Burlington, MA, United States of America

David A Swanson