Apotex Pharmachem Inc.

Apotex Inc.

David A Stradiotto

Allan W Rey

Daqing Che

Yajun Zhao

Probal Kanti Datta

Uma Kotipalli

Stephen E Horne

Zhi-Xian Wang

K S Keshava Murthy

Cameron L McPhail

Elena Bejan

Ks Keshava Murthy

Svetoslav S Bratovanov

Abbulu Kante

Matthew Pompili

Krista Lyn Traynor

Matthew A Pompili

A solid form of Nilotinib hydrochloride, which exists as a co-crystal of nilotinib hydrochloride and levulinic acid having a molar ratio of nilotinib hydrochloride to levulinic acid of 1:2, and a process for the preparation of the co-crystal.

Solid forms of nilotinib hydrochloride

Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.

Atorvastatin calcium propylene glycol solvates

An industrially acceptable process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine from a cis/trans mixture of isomers. Treatment of the mixture with an organic sulfonic acid generates a less soluble acid addition salt that is enriched in the cis-isomer. Recrystallization or pulping using various organic solvents allows for enrichment of the cis-isomer by filtration. These new sulfonic acid salts of the cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3&#x2032;)quiniclidine prepared according to the present invention could be further converted into the hydrochloride salt by any known procedures such as treatment with a base and then hydrochloric acid salt formation or exchange of the sulfonic acid salt with hydrochloric acid.

Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3')quiniclidine hydrochloride

A novel form of Ibandronate sodium which is particularly suitable for pharmaceutical applications, and a process for preparing said novel form.

Ibandronate sodium propylene glycol solvate and processes for the preparation thereof

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Brantford, Canada

David A Stradiotto