Mine Safety Appliances Company

The United States of America As Represented by the Department of Health

David A Stewart

Joseph D Jolson

RaeAnn M Auel

Alan A Schneider

John F Price

David B Danner

Mark J Nuell

J Keith McClung

The subject invention relates to a novel mammalian antiproliferative protein, prohibitin, and uses thereof. For example, prohibitin may be utilized in the treatment of diseases involving excess cellular replication, such as cancer, or in the treatment of conditions involving an insufficient amount of cellular replication, such as impaired tissue regeneration.

Antiproliferative protein

The present invention is for an electrochemical cell and method for quantitatively detecting noxious gas which comprises a first working electrode comprising a gas diffusion membrane having bonded thereto a catalytic portion electrochemically reactive with the noxious gas; a second working electrode having electrochemical activity with the oxidation/reduction products produced at the first working electrode; a counter electrode; a reference electrode; an electrolyte; means for containing said electrolyte and said electrodes; means for maintaining a fixed potential on said first working electrode relative to said reference electrode of from about 1.0 to 1.8 volts with respect to the potential of the reversible hydrogen couple of the electrolyte of the cell; and means for maintaining a fixed potential on said second working electrode relative to said reference electrode of from about 1.0 to 2.2 volts with respect to the potential of the reversible hydrogen couple of the electrolyte of the cell, the fixed potential on said working electrode being maintained at a voltage higher than the fixed potential being maintained on said first working electrode.

Electrochemical cell

Method for the detection of noxious gases

Electrochemical cell for the detection of noxious gases

Formaldehyde is determined by electrochemical oxidation of formaldehyde at an iridium electrode while maintaining the electrode at a fixed potential and measuring the current flowing through the electrode.

Electrochemical determination of formaldehyde

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Baltimore, MD, United States of America

David A Stewart