California Institute of Technology

Slipchip Corporation

Peraton Inc.

Talis Biomedical Corporation

David A Selck

Rustem F Ismagilov

Feng Shen

Liang Li

Stefano Begolo

Mikhail Karymov

Espir Kahatt

Mitchell Guttman

Erik B Jue

Philip Homewood

Matthew S Curtis

Chris Da Costa

Yu-Hsiang Hsu

Sam S Shekar

Philip James Homewood

Om Prakash, Ii

Stephanie McCalla

Dmitriy V Zhukov

H Morgan Crafts, Jr

Mary Arrastia

Jesus Rodriguez Manzano

Joe Baker

Methods, systems and related compositions are provided to perform single-cell marking of a nucleic acid and/or protein in a sample based on in-cell or in-organelle barcoding of nucleic acid and/or protein complexes of the cell or organelle; the methods and systems herein described are configured to provide in-cell or in-organelle single-cell marked nucleic acid and/or protein complexes comprising a single-cell, cell-specific, or a single-cell organelle-specific marker.

Methods and systems for performing single cell analysis of molecules and molecular complexes

A system for classifying an origin of genomic sequence data may include a training database comprising sample data including first samples corresponding to sequences of natural origin and second samples corresponding to sequences of synthetic origin, and a classifier comprising a genomic classification module. The genomic classification module may be trained via machine learning on the first and second samples. The genomic classification module may be configured to receive genomic sequence data of any read length and determine a classification output indicating whether the genomic sequence data has a natural origin or synthetic origin.

Apparatus and method for characterization of synthetic organisms

The present invention relates to methods, computer readable medium and systems for detecting and counting single nucleic acid molecules confined in nanoliter volumes using an unmodified camera, such as a cell phone camera. In particular, it identifies colorimetric amplification-indicator dyes that are compatible with the spectral sensitivity of standard mobile phones. The invention further provides an optimal ratiometric image-process for a selected dye to achieve a readout that is robust to lighting conditions and camera hardware and provides unambiguous quantitative results, even for colorblind users.

Devices and methods for direct visual detection and readout of single nucleic acid molecules

The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.

System and method for movement and timing control

The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.

Fluidic devices and systems for sample preparation or autonomous analysis

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Sterling, VA, United States of America

David A Selck