Newell Window Furnishings, Inc.

University of Colorado

National Jewish Health

Other

Musc Foundation for Research Development

Pegasus Solutions, Inc.

David A Schwartz

Thomas A Caputo

David C Roberts

Richard D Coulcher, Jr

Max Seibold

Roger C Palmer

Richard Coulcher

Tasha E Fingerlin

Weiming Zhang

Zazu Ciuca

Jian-yun Dong

James S Norris

Zdzislaw M Szulc

Joseph Potts

Yusuf A Hannun

Alicja Bielawska

Zazu Cicua

Christopher M Evans

Ian Stancil

Marvin I Schwarz

Ivana V Yang

Joyce S Lee

John McKillop

Paolo Hutchison

Christian Rivadalla

Thomes A Caputo

Jacek Bielawski

David H Holman

Ahmed M El-Zawahry

Jian-Yun Dong

John Mckillop

David Holman

Paolo Hutchinson

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.

Methods and compositions for risk prediction, diagnosis, prognosis, and treatment of pulmonary disorders

The present disclosure provides a method of treating a fibrotic lung disease in a subject comprising administering to the subject an effective amount of a therapeutic agent, wherein the subject is asymptomatic and wherein the subject is at risk of developing the fibrotic lung disease.

Biomarkers for the diagnosis and treatment of fibrotic lung disease

Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Methods for predicting risk of interstitial pneumonia

A method of screening a test compound, e.g., a fibrosis or IPF inhibitor, for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease includes culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium contacting the cultured cells with the test compound; and monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary; wherein stationary cultured cells indicate that the test compound induces the UJT. Also included are methods of identifying lung fibrosis biomarkers.

Fibrosis model and methods of use thereof

The invention provides the compounds of formula (): and pharmaceutically acceptable salts thereof, wherein R, R, R, R, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of formula (I) and their use in treating or preventing diseases associated with cell overproliferation and dysfunctional sphingolipid signal transduction. The invention also encompasses the use of the compounds in combination with an apoptosis-signaling ligand, such as Fas ligand. Preferably, the Fas ligand is administered in the form of a gene therapy agent. 

Ceramides and apoptosis-signaling ligand

An adjustable cord restraining device for a blind assembly having a head rail, a bottom rail and at least one pull cord extending through a cord passage of the head rail and coupled to the bottom rail includes an annular member sufficiently sized to prevent entry of the annular member into the cord passage of the head rail and further travel of the pull cord through the head rail. A method of preventing the further extension of a pull cord includes obtaining an annular member sized larger than a pull cord passageway of a head rail pinching a mid-section of the pull cord and inserting the pinched portion of the mid-section through the annular member, forming a loop with the pull cord, inserting a free end of the pull cord through the loop to form an adjustable knot.

Method and apparatus for fixing the length of a pull cord

A sizing center for and a method of sizing different styles of window coverings includes at least two sizing mechanisms disposed on a sizing center in which each sizing mechanism is adapted to size a different style of window covering. Each window covering includes a color marking. At least two measuring scales are disposed on the sizing center, each measuring scale being associated with a sizing mechanism and having a different color, and each color associated with a sizing center being associated with a color marking of a window covering.

Blind and shade cutting center for cutting two different window covering products

A sizing center for sizing different styles of window coverings includes at least two sizing mechanisms disposed on the sizing center in which each sizing mechanism is adapted to size a different style of window covering. The sizing center includes a squaring block for orienting a window covering on the sizing center. The squaring block includes a first side and a second side. A cutout for receiving a plurality of slats of a window covering is located in a top surface of the squaring block, the cutout extends from the first side of the squaring block to the second side of the squaring block.

A system for locating the center of a window covering relative to a cutting mechanism. The window covering including a head rail with a first end and a second end and a connector disposed approximately midway between the first end and the second end, the connector including an aperture. The system includes a locator that engages the connector and positions the window covering.

Blind and shade cutting center with center locating system

A method and apparatus for sizing window coverings slidably extendable from a bay into an aisle of a retail outlet. The method includes the steps of locating the center of the window covering relative to a cutting station utilizing a half scale for removing a portion of the window covering from each of its ends.

Blind and shade cutting center

Growing community of inventors

High Point, NC, United States of America

David A Schwartz