Johns Hopkins University

South Dakota State University

Other

Cera Products, Inc.

David A Sack

Weiping Zhang

Michael D Myers

Charles B Stephensen

Cheryl Mitchell

Charlene Riikonen

Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-LT). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.

Multiepitope fusion antigens and vaccines and their use in treatment of enterotoxigenic diarrhea

Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa--LT). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.

A food composition having a high protein level and comprising DHA, preferably for use as a meal replacement, is administered to subjects in order to control their weight.

Meal replacement compositions and weight control method

This invention provides for a composition base and method of formulation to allow for oral vaccine delivery. The composition base is mixed with the oral vaccine and includes a carbohydrate composition having a dextrose equivalency value within the approximate range of 35-50. The buffer composition includes an electrolyte composition blended with the carbohydrate composition and the blended carbohydrate and electrolyte compositions are mixed each with respect to the other and then with the vaccine for oral ingestion by a user.

Buffer composition base and method of formulation for oral vaccine

A non-invasive method for determining gastric acidity in humans, using oral magnesium metal powder while measuring the hydrogen gas response in exhaled breath and belches. The magnesium reacts with hydrochloric acid in the stomach liberating hydrogen and the magnitude of the hydrogen released is correlated with the amount of gastric acid produced.

Growing community of inventors

Fallston, MD, United States of America

David A Sack