University of Kentucky Research Foundation

Orthopeutics, L.p.

David A Puleo

Thomas P Hedman

Pawel Slusarewicz

Sharath C Sundararaj

Thomas D Dziubla

James Zach Hilt

Mike McQuinn

Theodora Asafo-Adjei

Paul Fisher

Vishwas Talwalkar

Todd Milbrandt

Bryan Orellana

A protein crosslinker delivery device includes a body and a protein crosslinker held in a synthetic or natural biodegradable polymer. The body, a coating on the body, or an attachment to the body can contain the protein crosslinker holding biodegradable polymer. The release rate of the crosslinker and total amount of crosslinker released can be controlled by varying the concentration of the crosslinker and by varying the composition and structural characteristics of the degradable polymer. Surface eroding, bulk eroding and naturally occurring biodegradable polymers can be used in conjunction with a variety of nontoxic or minimally-toxic protein crosslinking agents. The devices can be used to treat mechanically damaged, deformed, and nutritionally deficient connective or soft tissues such as the knee meniscus, the spinal disc, the cornea, ligaments and tendons, the soft palate, and skin.

Crosslinker enhanced repair of connective tissues

The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.

Small molecule drug release from in situ forming degradable scaffolds incorporating hydrogels and bioceramic microparticles

The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers degrade at separate rates, thereby providing sustained mechanical support and tailored drug delivery.

Bilayered calcium sulfate/calcium phosphate space-making composites with multiple drug delivery capabilities

The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.

Polymeric prodrug

Growing community of inventors

Lexington, KY, United States of America

David A Puleo